L-Dopa-induced release of cerebral monoamines

K Y NgI J Kopin


L-Dopa markedly increased the efflux of tritiated dopamine and tritiated serotonin from rat brain slices. This action appeared contingent on the decarboxylation of L-dopa to dopamine, since it could be blocked by an inhibitor of L-amino acid decarboxylase. Selective destruction of catecholamine-containing nerve terminals by 6-hydroxydopamine significantly decreased the uptake and release of tritiated dopamine but not that of tritiated serotonin. These observations support the hypothesis that a portion of exogenously administered L-dopa may enter central serotonin terminals and undergo decarboxylation to the amine with resultant displacement of the endogenous indoleamine from vesicular stores.


Jan 1, 1968·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·H Thoenen, J P Tranzer
Feb 1, 1970·Journal of Neurochemistry·N J Uretsky, L L Iversen
Apr 1, 1969·Journal of Neurochemistry·T N ChaseI J Kopin
Jan 1, 1962·Scandinavian Journal of Clinical and Laboratory Investigation·J HAGGENDAL

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Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·S A TresederP Jenner
Jan 1, 1971·Psychopharmacologia·J MajE Mogilnicka
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May 1, 1971·European Journal of Pharmacology·M KarobathM O Huttunen
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