PMID: 8584208Aug 11, 1995Paper

L-DOPA is converted to dopamine in serotonergic fibers of the striatum of the rat: a double-labeling immunofluorescence study

Neuroscience Letters
Ryohachi AraiIkuko Nagatsu

Abstract

The aim of the present study is to examine whether serotonergic terminals of the rat brain are induced to contain dopamine by L-DOPA administration. In rats that received intraperitoneally L-DOPA plus a peripheral decarboxylase inhibitor, we showed by use of a double-labeling immunofluorescence method that dopamine was localized in serotonergic fibers of the striatum and cerebral cortex as well as in serotonergic cell bodies of the midbrain raphe nuclei. In normal rats, no dopamine was detected in the serotonergic fibers or cell bodies. The finding suggests that a part of the administered L-DOPA may enter the serotonergic terminals and be converted to dopamine in the rat brain.

References

Aug 1, 1979·Neurology·S FahnW P Isgreen
Feb 5, 1990·Brain Research·G L Snyder, M J Zigmond
Jan 1, 1990·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·T BrannanM Yahr
Aug 1, 1987·Journal of Neurochemistry·J L ChagnaudM Geffard
Oct 2, 1970·Science·K Y NgI J Kopin
May 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·U K RinneM Hyyppä

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Apr 20, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Keiko Ikemoto
Aug 29, 1997·Neuroscience Letters·K IkemotoI Nagatsu
Jul 21, 2012·Neurology·Maria StamelouKailash P Bhatia
Feb 8, 2013·PloS One·Nina NevalainenIngrid Strömberg
Oct 19, 2011·Parkinson's Disease·Sylvia Navailles, Philippe De Deurwaerdère
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kenneth T KishidaP Read Montague
Jan 23, 2016·Pharmacology, Biochemistry, and Behavior·Melissa M ContiChristopher Bishop
May 9, 2012·Revue neurologique·P De Deurwaerdère, S Navailles
Jan 18, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Perdita A Cheshire, David R Williams
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Sep 1, 2011·Progress in Neurobiology·Philippe HuotJonathan M Brotchie
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Jun 11, 2008·Neurobiology of Aging·Yoshitaka KumakuraPaul Cumming
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Sep 1, 2006·Journal of Neurochemistry·M Angela Cenci, Martin Lundblad
Jul 6, 2012·The European Journal of Neuroscience·Christopher BishopKaren L Eskow Jaunarajs
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