l-Glutamine Attenuates DSS-Induced Colitis via Induction of MAPK Phosphatase-1

Nutrients
Soo-Yeon JeongSuhn-Young Im

Abstract

Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a multifactorial inflammatory disease of the small intestine and colon. Many investigators have reported that l-glutamine (Gln) therapy improves outcomes of experimental colitis models, although the mechanism is not fully understood. Regarding the anti-inflammatory properties of Gln, we have shown that Gln can effectively deactivate cytosolic phospholipase A₂ (cPLA₂) by rapid induction of MAPK phosphatase (MKP)-1. In this study, we explore the possibility that Gln ameliorates dextran sulfate sodium (DSS)-induced colitis via MKP-1 induction, resulting in inhibition of cPLA₂, which has been reported to play a key role in the pathogenesis of IBD. Oral Gln intake attenuated DSS-induced colitis. Gln inhibited cPLA₂ phosphorylation, as well as colonic levels of TNF-α and leukotriene (LT)B₄. Gln administration resulted in early and enhanced MKP-1 induction. Importantly, MKP-1 small interfering RNA (siRNA), but not control siRNA, significantly abrogated the Gln-mediated (1) induction of MKP-1; (2) attenuation of colitis (colon length, histological abnormality, and inflammation; and (3) inhibition of cPLA₂ phosphorylation and colonic levels of TNF-...Continue Reading

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Citations

Feb 27, 2020·Journal of the Endocrine Society·Siddhartha S GhoshShobha Ghosh
Mar 23, 2021·Clinical Nutrition ESPEN·Juliana Soares SeveroMoisés Tolentino
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sunmin ParkSong Mee Cho

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