L-hydroxytryptophan amplifies pulsatile secretion of LH in the follicular phase of normal women

Clinical Endocrinology
J Lado-AbealJ Cabezas-Cerrato

Abstract

The hypothalamus possesses serotoninergic fibres which arise from neuronal cell bodies located in the raphe nuclei and have synapse on GnRH-secreting neurones. Hitherto, no firm evidence has been produced to support a role for serotoninergic control of LH in humans. Our first objective was to investigate whether pulsatile administration of L-5-hydroxytryptophan--the immediate precursor of serotonin--affects pulsatile LH secretion in the medium-late follicular phase of normal women. Since the results of the first experiment suggest that L-5-hydroxytryptophan amplifies LH release, our second objective was to investigate whether, in the absence of GnRH, L-5-hydroxytryptophan can release LH. This was done by studying LH response in patients with hypogonadotrophic hypogonadism of hypothalamic origin. Twenty-two normal women (18-25 years old) and 8 patients with hypogonadotrophic hypogonadism (2 men with Kallmann's syndrome and 6 women with anorexia nervosa). Serum LH levels in the 22 subjects (reference population) were monitored at 10-minute intervals over an 8-hour period (1000-1800h) during medium-late follicular phase. In 7 of these subjects, serum LH levels were monitored in their next medium-late follicular phase while L-5-hyd...Continue Reading

Citations

Jul 28, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Saydur RahmanPeter Thomas
Jun 10, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·M G Katz, B Vollenhoven
Nov 5, 2014·Frontiers in Endocrinology·Bruno EstourNatacha Germain
Jan 1, 2010·International Journal of Tryptophan Research : IJTR·S ComaiC V L Costa

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