PMID: 7028125Sep 24, 1981Paper

L-Lactate as a source of carbon for fatty acid synthesis in adult and foetal sheep

Biochimica Et Biophysica Acta
J P RobertsonR G Vernon

Abstract

The contribution of carbon from acetate, glucose and L-lactate to fatty acid synthesis has been compared in adipose tissue from adult and foetal sheep. Adipose tissue slices were incubated with mixtures of acetate, glucose and L-lactate at concentrations found in sheep blood. Under these conditions acetate, glucose and L-lactate contributed 95, 2 and 3%, respectively, of the C2 units used for fatty acid synthesis in adipose tissue slices from adult sheep. In contrast, acetate, glucose and L-acetate provided 50, 17 and 33%, respectively, of the C2 units for fatty acid synthesis in adipose tissue slices from foetal lambs (about 30 days prior to birth). The contribution of acetate and L-lactate carbon to fatty acid synthesis varied with their concentrations over the normal physiological range at both ages. We conclude that L-lactate is normally a minor source of carbon for fatty acid synthesis in the adult sheep but is an important source in foetal lambs.

References

Apr 1, 1978·Physiological Reviews·F C Battaglia, G Meschia
Jan 1, 1979·The International Journal of Biochemistry·R G Vernon
Nov 1, 1978·The Journal of Nutrition·G B WhitehurstM H Crump
Feb 1, 1976·The American Journal of Physiology·V C Char, R K Creasy
Mar 1, 1973·Journal of Dairy Science·Y T Yang, R L Baldwin
Jan 1, 1972·The Biochemical Journal·F J BallardI G Jarrett
Dec 1, 1967·The American Journal of Physiology·A K KhachadurianB Adrouni
Nov 1, 1980·Molecular and Cellular Endocrinology·D J FlintR G Vernon
Jun 15, 1981·The Biochemical Journal·R G VernonD J Flint
Jan 1, 1980·Progress in Lipid Research·R G Vernon

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Citations

Jan 1, 1991·The International Journal of Biochemistry·C Y Hu, H J Mersmann
Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A Faulkner, R G Vernon
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R G VernonE Taylor
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R L HoodD C Johnson
Feb 15, 1983·Archives of Biochemistry and Biophysics·S B Smith
Mar 9, 2019·Evolution; International Journal of Organic Evolution·Omar WarsiDan I Andersson
Jun 1, 1983·The Proceedings of the Nutrition Society·T E Weekes
Dec 19, 1986·Biochimica Et Biophysica Acta·S R Behr, F B Kraemer

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