PMID: 7001252Nov 13, 1980Paper

L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase

A Sener, W J Malaisse


The release of insulin evoked by nutrients in the pancreatic beta-cell is attributed to either the activation of a stereospecific receptor by the nutrient molecule itself or the generation of one or more signal(s) through the intracellular metabolism of the nutrient secretagogue. The first of these hypotheses is apparently supported by the fact the nonmetabolized amino acids, especially the L-leucine analogue b(-)2-amino-bicyclo[2,2,1]heptane-2-carbocyclic acid (BCH), stimulate insulin release. However, we now report evidence in support of the second hypothesis. We present data consistent with the idea that BCH induces insulin release through the allosteric activation of glutamate dehydrogenase. This is compatible with the fuel hypothesis, which states that the secretory response to nutrient secretagogues depends always on an increase of catabolic fluxes in the islet cells.


Apr 1, 1979·Metabolism: Clinical and Experimental·W J MalaisseJ C Hutton
Nov 15, 1979·The Biochemical Journal·J C HuttonW J Malaisse
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·N FreinkelR M Dawson
Aug 13, 1971·Biochimica Et Biophysica Acta·H N ChristensenI B Täljedal
May 1, 1973·The Biochemical Journal·J D McGivanJ B Chappell


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Dec 4, 2004·Journal of Neuroscience Research·Vasileios MastorodemosAndreas Plaitakis
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·A Kelly, C Stanley
Jul 1, 1981·Molecular and Cellular Biochemistry·W J MalaisseF Malaisse-Lagae
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Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A SenerW J Malaisse
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Jun 15, 2004·BMC Endocrine Disorders·Subhadra C GunawardanaDavid W Piston
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Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·A KellyC Stanley
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May 23, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Rogério C PiresMaria Esméria C Amaral
Aug 15, 2014·Journal of Amino Acids·Jennifer F IversonFrank Q Nuttall
Dec 9, 2014·International Journal of Endocrinology·Ghada ElmhiriLatifa Abdennebi-Najar
Oct 28, 2011·Nutrition Reviews·Marika Leenders, Luc J C van Loon
Aug 24, 2001·Pediatric Research·P De LonlayJ M Saudubray
May 27, 2010·Nutrition Reviews·Jichun YangBryan A Wolf
Oct 15, 1984·Experientia·E GylfeB Täljedal
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