PMID: 8587651Aug 1, 1995Paper

L-lysine is a barbiturate-like anticonvulsant and modulator of the benzodiazepine receptor

Neurochemical Research
Y F Chang, X M Gao

Abstract

Our earlier observations showed that L-lysine enhanced the activity of diazepam against seizures induced by pentylenetetrazol (PTZ), and increased the affinity of benzodiazepine receptor binding in a manner additive to that caused by gamma-aminobutyric acid (GABA). The present paper provides additional evidence to show that L-lysine has central nervous system depressant-like characteristics. L-lysine enhanced [3H]flunitrazepam (FTZ) binding in brain membranes was dose-dependent and stimulated by chloride, bromide and iodide, but not fluoride. Enhancement of [3H]FTZ binding by L-lysine at a fixed concentration was increased by GABA but inhibited by pentobarbital between 10(-7) to 10(-3)M. While GABA enhancement of [3H]FTZ binding was inhibited by the GABA mimetics imidazole acetic acid and tetrahydroisoxazol pyridinol, the enhancement by pentobarbital and L-lysine of [3H]FTZ binding was dose-dependently increased by these two GABA mimetics. The above results suggest that L-lysine and pentobarbital acted at the same site of the GABA/benzodiazepine receptor complex which was different from the GABA binding site. The benzodiazepine receptor antagonist imidazodiazepine Ro15-1788 blocked the antiseizure activity of diazepam against P...Continue Reading

References

Jul 27, 1978·Nature·J F TallmanD W Gallager
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M Karobath, G Sperk
Nov 23, 1979·European Journal of Pharmacology·P Supavilai, M Karobath
Feb 1, 1978·Journal of Neurochemistry·Y E Chang
Jan 1, 1988·International Anesthesiology Clinics·R W Olsen
Aug 16, 1985·Neuroscience Letters·Y F Chang, N R Myslinski
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F Leeb-LundbergR W Olsen
Jul 9, 1982·European Journal of Pharmacology·K TakahamaY Kasé
Jan 26, 1981·Life Sciences·Y F ChangN R Myslinski
Dec 1, 1961·The Journal of Physiology·T ARAKIO OSCARSSON

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Citations

Jan 16, 2009·Bulletin of Experimental Biology and Medicine·L A SeveryanovaA A Kryukov
Oct 29, 1998·General Pharmacology·G Tunnicliff
Nov 22, 2012·The British Journal of Nutrition·Tomokazu TsurugizawaKunio Torii
Dec 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Miro Smriga, Kunio Torii
May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Miro SmrigaNevin S Scrimshaw
May 25, 2018·The International Journal of Neuroscience·E Samokhina, Alexander Samokhin
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Roman FurtmüllerHeinz Redl
Apr 20, 2019·International Journal of Molecular Sciences·Liudmila A SeveryanovaAlexey A Kriukov
Sep 2, 2020·International Journal of Molecular Sciences·Rochelin DalanginRobert E Campbell

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