L-ornithine L-aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis.

The Cochrane Database of Systematic Reviews
Ee Teng GohMarsha Y Morgan

Abstract

Hepatic encephalopathy is a common complication of cirrhosis and has high associated morbidity and mortality. The condition is classified as overt if it is clinically apparent or minimal if only evident though psychometric testing. The exact pathogenesis of this syndrome is unknown although ammonia is thought to play a key role. L-ornithine L-aspartate has ammonia-lowering properties and may, therefore, benefit people with cirrhosis and hepatic encephalopathy. To evaluate the beneficial and harmful effects of L-ornithine L-aspartate versus placebo, no intervention, or other active interventions in people with cirrhosis and hepatic encephalopathy. We undertook electronic searches of The Cochrane Hepato-Biliary Group Controlled Trials Register, CENTRAL, MEDLINE, Embase, LILACS and Science Citation Index Expanded to December 2017 and manual searches of meetings and conference proceedings; checks of bibliographies; and corresponded with investigators and pharmaceutical companies. We included randomised clinical trials, irrespective of publication status, language, or blinding. We included participants with cirrhosis who had minimal or overt hepatic encephalopathy or who were at risk for developing hepatic encephalopathy. We compare...Continue Reading

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Citations

Jun 18, 2019·The Cochrane Database of Systematic Reviews·Harry D ZachariasMarsha Y Morgan
Dec 24, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Xiqiao Wang, Bo Yuan
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Apr 1, 2020·The American Journal of Gastroenterology·Jasmohan S BajajSara Montagnese
Jul 12, 2019·World Journal of Hepatology·Daniela CampionCarlo Alessandria
Feb 23, 2020·BioMed Research International·Chongxiang ChenQingyu Zhao
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Mar 6, 2019·World Journal of Gastroenterology : WJG·David KockerlingAmeet Dhar
Dec 1, 2020·GE Portuguese Journal of Gastroenterology·Mariana Verdelho Machado

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