PMID: 7539045Jun 1, 1995Paper

L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites

The Journal of Experimental Medicine
T F TedderP Pizcueta

Abstract

L-selectin, a cell surface adhesion molecule that is expressed by most leukocytes, mediates leukocyte rolling along vascular endothelium at sites of inflammation. The contribution of L-selectin to leukocyte migration in models of chronic inflammation was assessed by using mice that lack cell surface L-selectin expression. Significant inhibition of neutrophil (56-62%), lymphocyte (70-75%), and monocyte (72-78%) migration into an inflamed peritoneum was observed 24 and 48 h after administration of thioglycollate, an inflammatory stimulus. L-selectin-deficient mice were also significantly impaired in delayed-type hypersensitivity reactions. Footpad swelling in response to sheep red blood cell challenge was reduced 75% in L-selectin-deficient mice compared with wild-type mice. Ear swelling in a model of contact hypersensitivity induced by oxazolone challenge was also reduced by 69% compared to wild-type mice. Consistent with L-selectin-mediating leukocyte migration into diverse vascular beds during inflammation, L-selectin-deficient mice were significantly resistant to death resulting from lipopolysaccharide (LPS)-induced toxic shock. LPS administration resulted in a 90% mortality rate in control mice after 24 h, while there was a ...Continue Reading

References

Feb 28, 1991·Nature·L J PickerE C Butcher
Oct 1, 1991·The Journal of Clinical Investigation·M S MulliganP A Ward
Apr 1, 1986·The American Journal of Dermatopathology·J R ChapmanG M Butchko
Feb 1, 1995·The Journal of Experimental Medicine·K LeyA L Beaudet
Jul 1, 1994·The Journal of Experimental Medicine·H XuJ C Gutierrez-Ramos
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J E SlighA L Beaudet

❮ Previous
Next ❯

Citations

Mar 29, 2002·European Journal of Immunology·Jennifer CzarneskiSusan R Ross
Nov 18, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Malhotra, M I Bird
Jan 1, 1996·International Journal of Clinical & Laboratory Research·G BertonC A Lowell
Apr 24, 2010·Cancer Immunology, Immunotherapy : CII·Suzanne Ostrand-Rosenberg
Jan 10, 2012·Journal of Clinical Immunology·Gabriela C FernándezMarina S Palermo
Jul 9, 2013·Trends in Molecular Medicine·Ralf J LudwigEnno Schmidt
Aug 7, 2002·The American Journal of Pathology·Jutta RenkonenRisto Renkonen
Oct 20, 1998·The American Journal of Pathology·Y ZouQ Xu
Sep 19, 1998·Journal of the Neurological Sciences·J J ArchelosH P Hartung
Dec 29, 1998·Transplantation Proceedings·H Beekhuizen, J S van de Gevel
Dec 4, 2001·Veterinary Immunology and Immunopathology·P S WeberJ L Burton
Jun 6, 2000·Advanced Drug Delivery Reviews·K KonstantopoulosL V McIntire
Feb 14, 2002·Resuscitation·Timothy H Rainer
May 16, 2000·Auris, Nasus, Larynx·L PospiechM Kubacka
May 26, 1999·Infectious Disease Clinics of North America·C Parent, P Q Eichacker
Mar 14, 1998·Research in Immunology·N Wagner
Oct 1, 1996·Current Opinion in Cell Biology·D DunonB A Imhof
Jun 11, 1998·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·G F Gerberick, E E Sikorski
Jun 24, 1999·Cytokine & Growth Factor Reviews·A Meager
Jun 28, 2003·Trends in Molecular Medicine·Klaus Ley
Aug 21, 2009·Expert Reviews in Molecular Medicine·James A Deane, Michael J Hickey
Jun 3, 2004·Nature Reviews. Immunology·Beat A Imhof, Michel Aurrand-Lions
Dec 3, 2005·Nature Reviews. Immunology·Siamon Gordon, Philip R Taylor
Oct 11, 2011·Nature Reviews. Immunology·Chao Shi, Eric G Pamer
Apr 3, 1999·British Journal of Pharmacology·J PanésD N Granger
Jun 16, 2001·British Journal of Pharmacology·J M MiotlaP G Hellewell
Jun 2, 1998·Kidney International·B J Ballermann
Feb 19, 2002·Kidney International·Bärbel Lange-SperandioRobert L Chevalier
Dec 22, 2010·The Journal of Biological Chemistry·Maria L AllendeRichard L Proia
Feb 1, 1996·The Journal of Experimental Medicine·J XuR A Flavell
Dec 1, 1996·The Journal of Experimental Medicine·M D CatalinaM H Siegelman
Feb 7, 1998·The Journal of Experimental Medicine·T G DiacovoU H von Andrian
Feb 7, 1998·The Journal of Experimental Medicine·R A WarnockU H von Andrian
Apr 3, 2001·The Journal of Experimental Medicine·A Hafezi-MoghadamK Ley
May 21, 2003·The Journal of Experimental Medicine·Markus SperandioKlaus Ley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.