Abstract
L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) remains a challenge in Parkinson's disease (PD) drug therapy. In the present study, we examined the effect of L-stepholidine (L-SPD), a known dual dopamine receptor agent, on LID in 6-hydroxydopamine (6-OHDA)-lesioned PD rat model. Daily administration of L-DOPA to PD rats for 22 days induced steady expression of LID, co-administration of L-SPD with L-DOPA significantly ameliorated LID without compromising the therapeutic potency of L-DOPA, indicating that L-SPD attenuated LID development. L-SPD alone elicited stable contralateral rotational behavior without inducing significant dyskinesia. Acute administration of L-SPD to rats with established LID produced significant relief of dyskinesia; this effect was mimicked by D(2) receptor antagonist haloperidol, but blunted by 5-HT(1A) receptor antagonist WAY100635. Furthermore, the mRNA level of 5-HT(1A) decreased significantly on 6-OHDA-lesioned striata, whereas chronic L-SPD treatment restored 5-HT(1A) receptor mRNA level on the lesioned striata. The present data demonstrated that L-SPD elicited antidyskinesia effects via both dopamine (D(2) receptor antagonistic activity) and nondopamine (5-HT(1A) agonistic activity) m...Continue Reading
References
Mar 1, 1992·Neurochemistry International·G Z JinB C Sun
Jan 1, 1997·Life Sciences·Z J DongG Z Jin
Jul 15, 1997·Biochemical Pharmacology·L L ZouG Z Jin
Oct 10, 1998·The European Journal of Neuroscience·M A CenciA Björklund
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Jun 27, 2000·Brain : a Journal of Neurology·C S LeeA Björklund
Oct 21, 2000·Journal of Neural Transmission·A Kaelin-LangJ M Burgunder
Oct 26, 2000·European Journal of Pharmacology·M D WoodG J Riley
Feb 15, 2001·Archives of Neurology·O RascolS Wright
Aug 3, 2001·Nature Reviews. Neuroscience·E BezardC E Gross
Jan 24, 2002·Trends in Pharmacological Sciences·Guo-Zhang JinYu Fu
Apr 1, 2003·Nature Neuroscience·Barbara PicconiPaolo Calabresi
May 13, 2003·Nature Medicine·Erwan BézardPierre Sokoloff
Apr 6, 2004·Synapse·Masahiko TomiyamaMasayuki Baba
Dec 4, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yi-Qing MoWei-Xing Shi
Dec 23, 2004·Journal of Neural Transmission·J M BrotchieK Venderova
May 12, 2005·Parkinsonism & Related Disorders·C GuigoniErwan Bezard
May 19, 2005·Experimental Neurology·M LundbladM A Cenci
Jul 12, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Jonathan M Brotchie
Jul 19, 2005·Pharmacology, Biochemistry, and Behavior·Jennifer L TaylorPaul D Walker
Dec 6, 2005·Brain Research Bulletin·Christelle MonvilleStephen B Dunnett
Aug 23, 2006·Acta Pharmacologica Sinica·Bart A EllenbroekGuo-zhang Jin
Dec 29, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Danqing XiaoMichael A Schwarzschild
Apr 25, 2007·Brain : a Journal of Neurology·Manolo CartaAnders Björklund
Jun 8, 2007·Neuropharmacology·Hai ZhangXuechu Zhen
Jan 29, 2008·Current Medicinal Chemistry·Jiao MoXuechu Zhen
Citations
May 20, 2011·Journal of Medicinal Chemistry·Hai ZhangAo Zhang
Jan 5, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Jian Yu WangChun Fu Wu
Jun 24, 2014·Pharmacology, Biochemistry, and Behavior·Rui ZhaoXuechu Zhen
Jul 2, 2015·Journal of Chemical Information and Modeling·Peng LianWei Fu
Jan 4, 2012·Journal of Ethnopharmacology·Ju-Xian SongYan-Bo Zhang
Apr 22, 2015·BMC Neuroscience·Keon Sung ShinMyung Koo Lee
Mar 29, 2014·Frontiers in Neural Circuits·Cristina MiguelezLuisa Ugedo
Sep 19, 2014·Psychopharmacology·Julie A MeadeDavid R Sibley
Sep 16, 2014·Parkinsonism & Related Disorders·Bing HanHua Zhao
Sep 4, 2012·Neurochemistry International·Golnasim RiahiThérèse Di Paolo
Dec 6, 2016·Expert Review of Neurotherapeutics·Hugo GeertsPatrick Roberts
Nov 6, 2015·Cell Death & Disease·J-R HaoC Gao
Jan 26, 2016·British Journal of Pharmacology·C MiguelezL Ugedo
Aug 31, 2010·Synapse·Ming GaoXue-Chu Zhen
Oct 23, 2013·Neuroreport·Kai YueChaoying Li
Jun 6, 2018·Frontiers in Molecular Neuroscience·Di-Sheng LuFeng Zhang
Jul 14, 2021·Acta Pharmacologica Sinica·Yuan-Bing HuangJie Wu
May 4, 2017·Journal of Chemical Information and Modeling·Sheng TianXuechu Zhen