L-Threonine Supplementation During Colitis Onset Delays Disease Recovery

Frontiers in Physiology
Joana GaifemRicardo Silvestre

Abstract

Dietary nutrients have emerged as potential therapeutic adjuncts for inflammatory bowel disease (IBD) given their impact on intestinal homeostasis through the modulation of immune response, gut microbiota composition and epithelial barrier stability. Several nutrients have already been associated with a protective phenotype. Yet, there is a lack of knowledge toward the most promising ones as well as the most adequate phase of action. To unveil the most prominent therapy candidates we characterized the colon metabolic profile during colitis development. We have observed a twofold decrease in threonine levels in mice subjected to DSS-induced colitis. We then assessed the effect of threonine supplementation in the beginning of the inflammatory process (DSS + Thr) or when inflammation is already established (DSS + Thr D8). Colitis progression was similar between the treated groups and control colitic mice, yet threonine had a surprisingly detrimental effect when administered in the beginning of the disease, with mice displaying a delayed recovery when compared to control mice and mice supplemented with threonine after day 8. Although no major changes were found in their metabolic profile, DSS + Thr mice displayed altered expression...Continue Reading

References

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Citations

Mar 4, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Jae Soung LeeHyung-Kyoon Choi
Oct 6, 2020·Disease Markers·Juan WuJunfeng Zhang
May 21, 2019·Frontiers in Immunology·Klara KostovcikovaMiloslav Kverka
Apr 2, 2021·Frontiers in Cellular and Infection Microbiology·Ang LiSuying Ding

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Methods Mentioned

BETA
Nuclear Magnetic Resonance
PCR
ELISA
NMR

Software Mentioned

R
SIMCA
GraphPad Prism

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