L-Tryptophan as a Novel Potential Pharmacological Treatment for Wound Healing via Aryl Hydrocarbon Receptor Activation

Dermatology : International Journal for Clinical and Investigative Dermatology
Neda BaroutiOlivier Sorg

Abstract

The aryl hydrocarbon receptor has been shown to be involved in wound healing. The aim of this study was to assess the effect of tryptophan on wound healing in vitro and in a clinical trial. The ability of tryptophan and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to increase wound healing was assessed in an in vitro scratch wound model in human keratinocytes. Topical tryptophan and vehicle were assessed for 12 weeks in 51 patients with lower limb ulcers that were resistant to conventional therapies. TCDD 0.1 nM and tryptophan 1 µM increased the rate of scratch recovery in a culture model. Topical tryptophan induced stronger pain relief and faster re-epithelialization than its vehicle in patients with lower limb ulcers. Tryptophan shows promising potential as a novel topical treatment for wound healing.

Citations

Sep 6, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kenneth S BrandenburgCharles J Czuprynski
Jan 10, 2017·Annual Review of Pathology·Matthew L WheelerDavid M Underhill
May 30, 2017·The Journal of Investigative Dermatology·Saori Morino-KogaMasutaka Furue
Oct 4, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Fabienne FontaoOlivier Sorg
Jun 18, 2017·International Journal of Oral Science·Stian A EngenKarl Schenck
Aug 30, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·F FontaoJ H Saurat
Jan 25, 2020·The Cochrane Database of Systematic Reviews·Cathryn BroderickRachel Forster
Aug 19, 2017·Scientific Reports·Xi-Hui LiJoon-Hee Lee
Jan 31, 2021·Biochemical Pharmacology·Ziyue Kou, Wei Dai
Dec 23, 2020·International Journal of Molecular Sciences·Iain A Murray, Gary H Perdew
Feb 23, 2021·Ocular Immunology and Inflammation·Anna Matysik-WoźniakRobert Rejdak
Aug 17, 2021·Scandinavian Journal of Gastroenterology·Sui WangYan-Bo Yu

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