L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications.

International Journal of Tryptophan Research : IJTR
Dawn M RichardDonald M Dougherty

Abstract

An essential component of the human diet, L-tryptophan is critical in a number of metabolic functions and has been widely used in numerous research and clinical trials. This review provides a brief overview of the role of L-tryptophan in protein synthesis and a number of other metabolic functions. With emphasis on L-tryptophan's role in synthesis of brain serotonin, details are provided on the research uses of L-tryptophan, particularly L-tryptophan depletion, and on clinical trials that have been conducted using L-tryptophan supplementation. The ability to change the rates of serotonin synthesis in the brain by manipulating concentrations of serum tryptophan is the foundation of much research. As the sole precursor of serotonin, experimental research has shown that L-tryptophan's role in brain serotonin synthesis is an important factor involved in mood, behavior, and cognition. Furthermore, clinical trials have provided some initial evidence of L-tryptophan's efficacy for treatment of psychiatric disorders, particularly when used in combination with other therapeutic agents.

References

May 1, 1977·Journal of Neurochemistry·A YuwilerL Braun
Sep 6, 1975·Lancet·D ChadwickC D Marsden
Sep 13, 1975·Lancet·D A MacSweeney
Nov 8, 1975·Lancet·K JensenA Nagy
Jul 1, 1976·Archives of General Psychiatry·B ShopsinS Gershon
Jun 27, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·A Carlsson, M Lindqvist
Jan 1, 1977·Experimental Eye Research·W H Oldendorf
Feb 21, 1976·British Medical Journal·B Rao, A D Broadhurst
Jul 8, 1976·Nature·P EtienneT L Sourkes
Nov 1, 1976·Archives of General Psychiatry·J WalinderR Bjorn-Erik
Aug 5, 1975·Biochimica Et Biophysica Acta·W M Pardridge, W H Oldendorf
Jan 1, 1976·The American Journal of Physiology·W H Oldendorf, J Szabo
Jan 1, 1992·Epidemiologic Reviews·E M Kilbourne
Nov 1, 1992·The International Journal of Neuroscience·R Sandyk
Nov 5, 1990·Brain Research·J D Schaechter, R J Wurtman
Apr 1, 1991·Journal of Behavioral Medicine·D J BowenE Fox
Jan 1, 1989·Psychopharmacology·S N YoungP Finn
Apr 1, 1989·The Journal of the American Dental Association·J W StockstillB Piniewski
Jul 1, 1989·The American Journal of Clinical Nutrition·N HrbotickyG H Anderson
Jan 1, 1986·Psychopharmacology·L Träskman-BendzA P Zis
Jul 1, 1988·Metabolism: Clinical and Experimental·B CaballeroR J Wurtman
Jan 1, 1986·Journal of Neural Transmission·H R LiebermanN Finer
Jan 1, 1986·European Neurology·E KörnerH Lechner
Jan 1, 1985·Psychopharmacology·S N YoungF R Ervin
Aug 1, 1985·The American Journal of Clinical Nutrition·H R LiebermanJ H Growdon
Sep 28, 1974·Lancet·R N HerringtonE C Johnstone
Jun 1, 1971·The American Journal of Clinical Nutrition·J E Leklem

❮ Previous
Next ❯

Citations

Jun 25, 2020·International Journal of Tryptophan Research : IJTR·Annalisa BosiAndreina Baj
Dec 26, 2018·Oxidative Medicine and Cellular Longevity·L A Ramos-ChávezV Pérez de la Cruz
Jan 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xinru GuNan Si
Apr 25, 2020·Frontiers in Microbiology·Shuli ChouAnshan Shan
Aug 28, 2020·Frontiers in Integrative Neuroscience·Ankita JenaNicole C Roy
May 11, 2011·Clinical Rheumatology·Yesim OzkanBolkan Simsek
Aug 8, 2013·International Journal of Tryptophan Research : IJTR·Akihiro MaetaKatsumi Shibata
Aug 1, 2015·Journal of Molecular Modeling·Adriana Pérez-GonzálezAnnia Galano
Jul 28, 2016·Scientific Reports·Mineko TeraoEnrico Garattini
Jul 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ling ZhaoZhao-Xiang Bian
May 18, 2017·Journal of Pineal Research·Kunal SharanVijay K Yadav
Aug 26, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Niamh M DenihanDeirdre M Murray
Jan 26, 2018·The Proceedings of the Nutrition Society·E L Gibson
Jan 27, 2019·Systems Biology in Reproductive Medicine·Mehmet KocabaşNadir Başçınar
Oct 28, 2019·The Journal of Physiology·Matteo M PuscedduMélanie G Gareau
Jan 12, 2020·Current Topics in Medicinal Chemistry·Abhishek WadhawanTeodor T Postolache
Nov 16, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Katharina KurzDietmar Fuchs
Jan 15, 2015·Journal of Psychopharmacology·Abdulla A-B Badawy, Donald M Dougherty
Aug 8, 2013·International Journal of Tryptophan Research : IJTR·Musthafa Mohamed EssaGilles J Guillemin
Dec 18, 2014·Journal of Clinical Gastroenterology·Grazia D FemminellaPaul Edison
Feb 15, 2017·The Journal of Headache and Pain·Claudia Francesca GaspariniLyn Robyn Griffiths
May 5, 2017·International Journal of Tryptophan Research : IJTR·Subrata DebnathJason C O'Connor
Jun 14, 2017·Metabolic Brain Disease·Joanna Kałużna-CzaplińskaGeir Bjørklund
Jun 22, 2017·Antioxidants & Redox Signaling·Joshua P Fessel, William M Oldham
Apr 1, 2018·Journal of Veterinary Internal Medicine·Aarti KathraniEdward J Hall
Jan 30, 2018·Cellular & Molecular Immunology·Lijie ZhaiDerek A Wainwright
Feb 6, 2019·Psychiatry and Clinical Neurosciences·Bogna Grygiel-GórniakMariusz Puszczewicz
Jan 18, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Katrin NitzDorothee Atzler
Apr 2, 2020·Nutrients·Hannah BinksSaman Khalesi
Aug 2, 2013·Journal of Psychopharmacology·Abdulla A-B Badawy
Apr 26, 2013·The Journal of Nutrition·Chiaki HiratsukaKatsumi Shibata
Feb 23, 2017·Anais Da Academia Brasileira De Ciências·Luana C A SilvaVânia D'Almeida
Aug 20, 2015·BMC Infectious Diseases·Priyesh BipathMargaretha Viljoen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.