PMID: 7378409May 23, 1980Paper

L-Tryptophan transport in human red blood cells

Biochimica Et Biophysica Acta
R RosenbergJ C Ellory


1. The initial rate of L-tryptophan uptake into human red cells as a function of the concentration in the medium was studied at 25 and 37 degrees C. 2. Uptake was resolved into saturable and linear components. Kinetic constants at 37 degrees C were, apparent Km 1.55 mM, V 0.145 mmol/l cell water per min and apparent KD 0.0103 min-1. 3. Inhibitor studies showed that L-tryptophan transport via the saturable component represents uptake by a previously unidentified transport system, designated the T-system. The linear component represents L-tryptophan transport via the L-system. 4. The substrate specificity of the T-system is apparently limited to the aromatic amino acids, L- and D-tryptophan, L-tyrosine and L-phenylalanine. The main route of L-phenylalanine transport is, however, via the L system. L-Tyrosine is partly transported via the T-system, partly via the L-system.


Jan 1, 1979·Progress in Neuro-psychopharmacology·R Rosenberg, O J Rafaelsen
Jun 28, 1979·Nature·J D YoungJ C Ellory
Jan 1, 1977·Journal of Neurochemistry·W M Pardridge, W H Oldendorf
Mar 1, 1976·The American Journal of Physiology·R H EndersC H Smith
Jan 15, 1976·The Biochemical Journal·J D YoungE M Tucker
May 1, 1972·Metabolism: Clinical and Experimental·J D Gardner, A G Levy
Mar 1, 1972·The Journal of Physiology·D G Hoare
Sep 3, 1968·Biochimica Et Biophysica Acta·H N Christensen

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