PMID: 7378409May 23, 1980Paper

L-Tryptophan transport in human red blood cells

Biochimica Et Biophysica Acta
R RosenbergJ C Ellory

Abstract

1. The initial rate of L-tryptophan uptake into human red cells as a function of the concentration in the medium was studied at 25 and 37 degrees C. 2. Uptake was resolved into saturable and linear components. Kinetic constants at 37 degrees C were, apparent Km 1.55 mM, V 0.145 mmol/l cell water per min and apparent KD 0.0103 min-1. 3. Inhibitor studies showed that L-tryptophan transport via the saturable component represents uptake by a previously unidentified transport system, designated the T-system. The linear component represents L-tryptophan transport via the L-system. 4. The substrate specificity of the T-system is apparently limited to the aromatic amino acids, L- and D-tryptophan, L-tyrosine and L-phenylalanine. The main route of L-phenylalanine transport is, however, via the L system. L-Tyrosine is partly transported via the T-system, partly via the L-system.

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Citations

Jan 1, 1981·The Journal of Membrane Biology·R Rosenberg
Jan 1, 1982·The Journal of Membrane Biology·M S Kilberg
Jan 1, 1985·The Journal of Membrane Biology·H N Christensen
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