L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons

Stroke; a Journal of Cerebral Circulation
A PisaniG Bernardi

Abstract

Experimental evidence supports a major role of increased intracellular calcium [Ca2+]i levels in the induction of neuronal damage during cerebral ischemia. However, the source of Ca2+ rise has not been fully elucidated. To clarify further the role and the origin of Ca2+ in cerebral ischemia, we have studied the effects of various pharmacological agents in an in vitro model of oxygen (O2)/glucose deprivation. Pyramidal cortical neurons were intracellularly recorded from a slice preparation. Electrophysiological recordings and microfluorometric measurements of [Ca2+]i were performed simultaneously in slices perfused with a glucose-free physiological medium equilibrated with a 95% N2/5% CO2 gas mixture. Eight to twelve minutes of O2/glucose deprivation induced an initial membrane hyperpolarization, followed by a delayed, large but reversible membrane depolarization. The depolarization phase was accompanied by a transient increase in [Ca2+]i levels. When O2/glucose deprivation exceeded 13 to 15 minutes, both membrane depolarization and [Ca2+]i rise became irreversible. The dihydropyridines nifedipine and nimodipine significantly reduced either the membrane depolarization or the [Ca2+]i elevation. In contrast, tetrodotoxin had no ef...Continue Reading

References

May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P J HoehnerG Fiskum
Oct 1, 1992·Journal of Neurophysiology·V Lev-RamW N Ross
May 1, 1990·The Journal of General Physiology·I A Silver, M Erecińska
Jan 1, 1988·Annals of the New York Academy of Sciences·B K Siesjö
Apr 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö, F Bengtsson
Jul 1, 1989·Journal of Neurophysiology·K Krnjević, J Leblond
Jun 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K AbeT Watanabe
Oct 1, 1985·Journal of Neurophysiology·D A McCormickD A Prince
Dec 1, 1982·Journal of Neurophysiology·B W ConnorsD A Prince
Aug 1, 1995·Brain : a Journal of Neurology·P CalabresiG Bernardi
Jan 1, 1995·European Neurology·M Fisher
Mar 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KatsutaA Tamura
Jan 1, 1994·Progress in Brain Research·D W Choi
Mar 1, 1994·Journal of Neurophysiology·N B MercuriG Bernardi
Dec 1, 1996·Archives of Neurology·T Brott

❮ Previous
Next ❯

Citations

Feb 17, 2000·European Journal of Pharmacology·S W Rabkin, J Y Kong
Jan 5, 2000·Journal of Diabetes and Its Complications·B FülesdiL Csiba
Nov 21, 1998·The European Journal of Neuroscience·A PisaniT Knöpfel
Dec 20, 2012·Stroke Research and Treatment·Marcel A KampDaniel Hänggi
Oct 16, 2004·Journal of Neurosurgery·Michael F StiefelPeter D LeRoux
Mar 20, 2009·Journal of Neurosurgical Anesthesiology·Michael HaileAlex Bekker
Aug 11, 2012·British Journal of Anaesthesia·M J RowlandK T S Pattinson
Nov 21, 2008·Clinical and Experimental Hypertension : CHE·Daniele TomassoniFrancesco Amenta
Jun 9, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Shimon LechtPhilip Lazarovici
Dec 29, 2009·Progress in Neurobiology·Dongman Chao, Ying Xia
Aug 25, 2009·Free Radical Biology & Medicine·Stephanie L H ZeigerBethAnn McLaughlin
Mar 17, 2009·European Journal of Pharmacology·Bahareh Tavakoli-FarMassoud Mahmoudian
Mar 4, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Congwu DuHelene Benveniste
Jul 21, 2004·Cell Calcium·Hang Yao, Gabriel G Haddad
Aug 25, 2001·Experimental Eye Research·H KuriyamaM Tsuda
Dec 3, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Katja SygneckaHeike Franke
Nov 20, 2002·Annals of the New York Academy of Sciences·M F Cano-AbadM G Lopez
Nov 22, 2017·Journal of Cerebrovascular and Endovascular Neurosurgery·Eun-Sung ParkSung-Don Kang
Nov 15, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Darcy LidingtonSteffen-Sebastian Bolz
Sep 1, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew J RowlandKyle Ts Pattinson
Aug 14, 2001·The Journal of Biological Chemistry·M F Cano-AbadM G López
Jun 20, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jae Joon HanChi Kyou Lee
Dec 2, 2020·International Journal of Molecular Sciences·Jonas OrtUte Lindauer
Aug 6, 2021·Proceedings of the National Academy of Sciences of the United States of America·Hiroo TakahashiAkio Tsuboi
Jul 31, 2021·Journal of the American Heart Association·William S DoddNohra Chalouhi
Aug 10, 2021·Frontiers in Neurology·Darcy LidingtonSteffen-Sebastian Bolz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Pathophysiology : the Official Journal of the International Society for Pathophysiology
Nahid Rahbar-RoshandelMassoud Mahmoudian
Journal of Neurological Surgery. Part A, Central European Neurosurgery
C SchellerK Scheller
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Beatriz Pérez-CadahíaJames R Davie
© 2021 Meta ULC. All rights reserved