PMID: 2497448Mar 1, 1989Paper

L-tyrosine, L-dopa, and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma cells

Pigment Cell Research
Andrzej SlominskiE Kuklinska

Abstract

In cultured cells of the Bomirski Ab amelanotic hamster melanoma line, the substrates of tyrosinase, L-tyrosine, and L-DOPA induce the melanogenic pathway. In this report, we demonstrate that these substrates regulate the subcellular apparatus involved in their own metabolism and that this regulation is under the dynamic control of one of the components of this apparatus, tyrosinase, via tyrosine hydroxylase activity. Culturing cells with nontoxic but melanogenically inhibitory levels of phenylthiourea (PTU; 100 microM) strongly inhibits induction of both the tyrosine hydroxylase and DOPA oxidase activities of tyrosinase by L-tyrosine (200 microM) but has no effect on the induction of either activity by L-DOPA (50 microM). De novo synthesis of premelanosomes precedes the onset of tyrosine-induced melanogenesis. Thereafter, increases in the population of melanosomes (likewise inhibited by PTU) correlate positively with increases in tyrosinase activity induced by L-tyrosine. Melanogenesis induced by L-DOPA in the absence of L-tyrosine is rate-limited not by tyrosinase but by inadequate melanosome synthesis. Our findings indicate that in Bomirski Ab amelanotic hamster melanoma cells the synthesis of the subcellular apparatus of me...Continue Reading

References

Jul 1, 1987·The Journal of Investigative Dermatology·M McEwan, P G Parsons
Jun 1, 1988·Cancer Metastasis Reviews·A BomirskiJ Bigda
Aug 16, 1985·Biochimica Et Biophysica Acta·M MirandaA Arcadi
Jan 1, 1973·Archiv Für Dermatologische Forschung·A BomirskiF Pautsch
May 1, 1968·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A B NovikoffL Biempica
Jan 1, 1984·The International Journal of Biochemistry·P W ScisłowskiA Bomirski
Jan 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·P FLESCH

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Citations

Jun 1, 1988·Cancer Metastasis Reviews·A BomirskiJ Bigda
Jul 15, 1991·Experientia·A Slominski, R Costantino
Oct 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·U Schraermeyer
May 15, 2003·Biochemical and Biophysical Research Communications·Marzia PerluigiChiara Cini
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·D A Brown
Feb 1, 1994·Pigment Cell Research·U Schraermeyer
Aug 13, 2011·Pigment Cell & Melanoma Research·Andrzej SlominskiJohn Pawelek
Sep 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A Slominski
Oct 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria KokkinakiNady Golestaneh
Mar 27, 2015·International Journal of Molecular Sciences·Tomasz WasiewiczMichal A Zmijewski
Sep 8, 2015·International Journal of Molecular Sciences·Shing-Yi Sean WuZhi-Hong Wen
Jan 19, 2005·The Journal of Investigative Dermatology·Andrzej SlominskiDesmond J Tobin
Jun 30, 2009·Experimental Dermatology·Andrzej Slominski
Aug 8, 2009·Experimental Dermatology·P M PlonkaK U Schallreuter
Aug 22, 2003·Experimental Dermatology·Przemyslaw M PlonkaKrystyna Urbanska
Mar 8, 1990·Journal of Theoretical Biology·A Slominski, R Paus
Nov 7, 2013·Dermato-endocrinology·Blazej ZbytekAndrzej Slominski
Apr 20, 2016·International Journal of Molecular Sciences·Bum-Ho BinEun-Gyung Cho
Jun 10, 2016·Archives of Dermatological Research·Yong Hyun KimJae Sung Hwang
Nov 19, 2015·PloS One·Xueping WangYong Feng
Jun 28, 2016·International Journal of Molecular Sciences·Pengchao WangChangsheng Dong
Jul 20, 2016·International Journal of Molecular Sciences·Stacey A N D'MelloMarjan E Askarian-Amiri
Dec 23, 2017·International Journal of Molecular Sciences·Insik Hwang, Sunghoi Hong
Sep 24, 2004·Physiological Reviews·Andrzej SlominskiJacobo Wortsman
Dec 27, 2018·International Journal of Molecular Sciences·Li LiuJing Shang
Nov 20, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irit AdiniRobert J D'Amato
Oct 21, 2000·Endocrine Reviews·A Slominski, J Wortsman
Feb 22, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Andrzej T SlominskiCraig A Elmets
Dec 4, 2019·Indian Journal of Dermatology, Venereology and Leprology·Rashmi SarkarPallavi Ailawadi

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