L1 (CD171) as a novel biomarker for ovarian and endometrial carcinomas

Expert Review of Molecular Diagnostics
Mina FogelAlon Ben-Arie

Abstract

The L1 molecule has emerged as a promising new biomarker for the diagnosis and prognosis of human ovarian and endometrial tumors. It was initially described as an adhesion molecule for neural cells but its function on tumor cells is less well known. In this article, the role of L1 in promoting tumor cell adhesion and migration is discussed. The question of how L1 determination in tumor tissue samples, serum and ascites could potentially improve the diagnosis and monitoring of gynecologic tumor patients is also addressed. The presence of L1 in tissue and serum was found to be associated with recurrent disease and short survival, independently of the tumor's histological type. This provides an alternative classification of gynecologic tumors according to their aggressiveness rather than their histology. L1 expression was correlated with disease progression even in patients with Stage I endometrioid-type endometrial tumors, identifying them as high-risk patients on preoperative curettage specimens. Monitoring of soluble L1 during the follow-up period was found to signal disease progression and recurrence before clinical symptoms occur. L1-based diagnosis and prognosis has the potential to contribute to an improved disease manageme...Continue Reading

References

Jun 24, 1998·The Journal of Experimental Medicine·G Di SciulloS A Bogen
Aug 24, 1999·The Journal of Biological Chemistry·M OleszewskiP Altevogt
Nov 14, 2001·The Journal of Cell Biology·S MechtersheimerP Altevogt
Feb 28, 2002·Lancet·Emanuel F PetricoinLance A Liotta
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paul GutweinD Peter Altevogt
Feb 22, 2003·Current Treatment Options in Oncology·Felice D Lackman, Peter S Craighead
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert C Bast
Dec 12, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Bruce A WernessM Steven Piver
Feb 7, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·W T CreasmanS Pecorelli

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Citations

Jun 27, 2015·International Journal of Cancer. Journal International Du Cancer·Peter AltevogtMina Fogel
Jan 5, 2011·The Journal of Surgical Research·Tamina RawnaqJussuf T Kaifi
Oct 8, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chao SunHong Zhang
Nov 11, 2016·Archives of Gynecology and Obstetrics·Michał WojciechowskiAndrzej Malinowski
Jan 28, 2006·World Journal of Gastroenterology : WJG·Jussuf T KaifiJakob R Izbicki
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jürgen GrünbergP August Schubiger

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