L1 Cell Adhesion Molecule as a Predictor of Disease-Specific Survival and Patterns of Relapse in Endometrial Cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Annukka PasanenMikko Loukovaara

Abstract

The aim was to study the association of L1 cell adhesion molecule (L1CAM) expression with the outcome of patients with endometrial cancer, especially with regard to conventional risk variables, and to compare the patterns of relapse in L1CAM-positive and -negative cancers. This was a retrospective study of 805 women. The Kaplan-Meier method and univariate and multivariate Cox regression models were applied for survival analyses. Missing data were replaced using multiple imputation. The median follow-up time was 51 months (range, 1-98). One hundred twenty-one (15.0%) cases were L1CAM positive. L1CAM positivity was associated with high stage (I vs II-IV) (odds ratio [OR], 2.3), lymph node involvement (OR, 2.9), poor differentiation (OR, 6.1), non-endometrioid histology (OR, 9.9), lymphovascular space invasion (OR, 2.8), cervical stromal invasion (OR, 1.8), positive peritoneal cytology (OR, 4.1), and age older than 65 years (OR, 2.8). The frequencies of deep myometrial invasion (50% or deeper), tumor size 2 cm or greater, and body mass index 30 kg/m2 or greater were not significantly different between L1CAM-positive and -negative cases. L1CAM predicted poor disease-specific survival in endometrioid (P < 0.0001) but not in non-endo...Continue Reading

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Citations

Jan 31, 2017·International Journal of Molecular Sciences·Francesca Angiolini, Ugo Cavallaro
Sep 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Annukka PasanenRalf Bützow
Feb 16, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Annukka PasanenRalf Bützow
Sep 25, 2017·Histopathology·Oluwole FadareXuan J Wang
Mar 29, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anni NiskakoskiPäivi Peltomäki
Mar 23, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anne Maarit KolehmainenMikko Loukovaara
Mar 25, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Laura C HautalaHannu Koistinen
Oct 24, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Annukka PasanenRalf Bützow
Nov 16, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Anne M KolehmainenMikko J Loukovaara
Jul 14, 2021·Gynecologic Oncology·Jasper VictoorIsabelle Vanden Bempt

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Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

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