L1 cell adhesion molecule as a therapeutic target in cancer

Expert Review of Anticancer Therapy
Xin-Zhe YuChen Jin

Abstract

L1 cell adhesion molecule (L1CAM) is the prototype member of the L1-family of closely related neural adhesion molecules. L1CAM is differentially expressed in the normal nervous system as well as pathological tissues and displays a wide range of biological activities. In human malignancies, L1CAM plays a vital role in tumor growth, invasion and metastasis. Recently, increasing evidence has suggested that L1CAM exerts a variety of functions at different steps of tumor progression through a series of signaling pathways. In addition, L1CAM has been identified as a promising target for cancer therapy by using synthetic and natural inhibitors. In this review, we provide an up-to-date overview of the role of L1CAM involved in cancers and the rationale for L1CAM as a novel molecular target for cancer therapy.

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Citations

Sep 25, 2017·Histopathology·Oluwole FadareXuan J Wang
Sep 29, 2019·Current Medicinal Chemistry·Weiqi Xia, Chunqi Hu

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