L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial-mesenchymal transition

Virchows Archiv : an International Journal of Pathology
Mac VersluisH Hollema

Abstract

Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial-mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAM is an adhesion molecule that has been involved in EMT as a marker for mesenchymal phenotype. We examined expression of L1CAM in UCS in a cohort of 90 cases from four different centers. Slides were immunohistochemically stained for L1CAM and scored in four categories (0%, < 10%, 10-50%, and > 50%). A score of more than 10% was considered positive for L1CAM. The median age at presentation was 68.6 years, and half of the patients (53.3%) presented with FIGO stage 1 disease. Membranous L1CAM expression was positive in the epithelial component in 65.4% of cases. Remarkably, expression was negative in the mesenchymal component. In cases where both components were intermingled, expression limited to the epithelial component was confirmed by a double stain for L1CAM and keratin. Expression of L1CAM did not relate to overall or disease-free survival. Our findings suggest L1CAM is either not a marker for the mesenchymal phenotype in EMT, or UCS is not a good model for EMT.

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Citations

Nov 23, 2019·British Journal of Cancer·Takashi IchikawaMasato Kusunoki
Nov 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ileana C CuevasDiego H Castrillon
Jul 22, 2019·Cancers·Susanna LeskelaJosé Palacios
May 6, 2020·Journal of Clinical Pathology·Joao Paulo Mancusi de CarvalhoJesus Paula Carvalho

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