LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Sarthak MatravadiaGraham P Holloway

Abstract

While the cause of Type 2 diabetes remains poorly defined, the accumulation of reactive lipids within white adipose tissue, skeletal muscle, and liver have been repeatedly implicated as underlying mechanisms. The ability of polyunsaturated fatty acids (PUFAs) to prevent the development of insulin resistance has gained considerable interest in recent years; however, the mechanisms-of-action remain poorly described. Therefore, we determined the efficacy of diets supplemented with either linoleic acid (LA) or α-linolenic acid (ALA) in preventing insulin resistance and reactive lipid accumulation in key metabolic tissues of the obese Zucker rat. Obese Zucker rats displayed impaired glucose homeostasis and reduced n-3 and n-6 PUFA content in the liver and epididymal white adipose tissue (EWAT). After the 12-wk feeding intervention, both LA- and ALA-supplemented diets prevented whole body glucose and insulin intolerance; however, ALA had a more pronounced effect. These changes occurred in association with n-3 and n-6 accumulation in all tissues studied, albeit to different extents (EWAT > liver > muscle). Triacylglycerol (TAG), diacylglycerol (DAG), ceramide, and sphingolipid accumulation were not attenuated in obese animals suppleme...Continue Reading

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May 23, 2014·American Journal of Physiology. Endocrinology and Metabolism·Sarthak MatravadiaGraham P Holloway

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Citations

Apr 4, 2017·Journal of Cellular Physiology·Marta GarbowskaAnna Zalewska
Feb 9, 2017·Diabetes·Mary Courtney MooreAlan D Cherrington
Apr 24, 2018·European Journal of Clinical Investigation·Chia-Yu WangChing-Yi Chen
Nov 4, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zane ChornerGraham P Holloway
Mar 9, 2017·American Journal of Physiology. Endocrinology and Metabolism·Paula M MiottoGraham P Holloway
Jul 8, 2021·American Journal of Physiology. Endocrinology and Metabolism·Geneviève J DesOrmeauxGraham P Holloway
Feb 26, 2019·Life Sciences·Klaudia BerkKarolina Konstantynowicz-Nowicka

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