Lab-on-a-Valve Mesofluidic Platform for On-Chip Handling of Carbon-Coated Titanium Dioxide Nanotubes in a Disposable Microsolid Phase-Extraction Mode

Analytical Chemistry
M T García-ValverdeManuel Miró

Abstract

Mesofluidic lab-on-a-valve (LOV) platforms have been proven suitable to accommodate automatic micro-solid-phase extraction (μSPE) approaches with on-chip handling of micrometer-bead materials in a fully disposable mode to prevent sample cross-contamination and pressure-drop effects. The efficiency of the extraction process notably depends upon the sorptive capacity of the material because the sorbent mass is usually down to 10 mg in LOV devices. Nanomaterials, capitalizing upon their enhanced surface-to-volume ratio and diversity of potential chemical moieties, are appealing alternatives to microbead sorbents. However, the handling and confinement of nanomaterials in fluidic chip structures have been challenging to date. This is most likely a consequence of the aggregation tendency of a number of nanomaterials, including carbon-based sorbents, that leads to excessive back-pressure in flowing systems along with irreproducible bead loading. This paper addresses these challenges by ad hoc synthesis of hybrid nanomaterials, such as porous carbon-coated titanium dioxide nanotubes (TiO2-NT@pC). Tailoring of the surface polarity of the carbon coating is proven to foster the dispersion of TiO2-NT@pC in LOV settings while affording supe...Continue Reading

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Citations

Mar 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hoda GhambariSoledad Cárdenas
Mar 29, 2021·Talanta·Francisco Antonio Casado-CarmonaSoledad Cárdenas
Apr 18, 2021·Analytica Chimica Acta·Francisco Pena-PereiraElefteria Psillakis
Dec 7, 2018·Analytical Chemistry·David J Cocovi-SolbergManuel Miró
Oct 23, 2019·Analytical Chemistry·Alexander S KaplitzJames P Grinias

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