Label Adherence for Non-Vitamin K Antagonist Oral Anticoagulants in a Prospective Cohort of Asian Patients with Atrial Fibrillation

Yonsei Medical Journal
So-Ryoung LeeEue-Keun Choi

Abstract

Label adherence for non-vitamin K antagonist oral anticoagulants (NOACs) has not been well evaluated in Asian patients with non-valvular atrial fibrillation (AF). The present study aimed to assess label adherence for NOACs in a Korean AF population and to determine risk factors of off-label prescriptions of NOACs. In this COmparison study of Drugs for symptom control and complication prEvention of AF (CODE-AF) registry, patients with AF who were prescribed NOACs between June 2016 and May 2017 were included. Four NOAC doses were categorized as on- or off-label use according to Korea Food and Drug Regulations. We evaluated 3080 AF patients treated with NOACs (dabigatran 27.2%, rivaroxaban 23.9%, apixaban 36.9%, and edoxaban 12.0%). The mean age was 70.5±9.2 years; 56.0% were men; and the mean CHA₂DS₂-VASc score was 3.3±1.4. Only one-third of the patients (32.7%) was prescribed a standard dose of NOAC. More than one-third of the study population (n=1122, 36.4%) was prescribed an off-label reduced dose of NOAC. Compared to those with an on-label standard dosing, patients with an off-label reduced dose of NOAC were older (≥75 years), women, and had a lower body weight (≤60 kg), renal dysfunction (creatinine clearance ≤50 mL/min), pr...Continue Reading

References

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Citations

Apr 25, 2020·Journal of Comparative Effectiveness Research·Carmen Suárez FernándezFrancesc Formiga
Jun 5, 2020·Journal of the American Heart Association·Hee Tae YuBoyoung Joung
Jun 20, 2020·European Geriatric Medicine·José Paulo Henriques Cabral Lopes de AlmeidaLino Gonçalves
Jun 27, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Edgar TayAndrew Wong
Nov 23, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Carlos Escobar, A John Camm
Aug 28, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Mario BoGaetano Maria De Ferrari
Jan 9, 2021·Stroke; a Journal of Cerebral Circulation·Soonil KwonGregory Y H Lip
Jan 21, 2021·European Heart Journal. Cardiovascular Pharmacotherapy·So-Ryoung LeeGregory Y H Lip
Apr 26, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jan SteffelUNKNOWN External reviewers
Sep 10, 2021·Stroke; a Journal of Cerebral Circulation·So-Ryoung LeeGregory Y H Lip

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Clinical Trials Mentioned

NCT02786095

Software Mentioned

SPSS
iCReaT

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