Label-Free Biosensor Imaging on Photonic Crystal Surfaces

Sensors
Yue Zhuo, Brian T Cunningham

Abstract

We review the development and application of nanostructured photonic crystal surfaces and a hyperspectral reflectance imaging detection instrument which, when used together, represent a new form of optical microscopy that enables label-free, quantitative, and kinetic monitoring of biomaterial interaction with substrate surfaces. Photonic Crystal Enhanced Microscopy (PCEM) has been used to detect broad classes of materials which include dielectric nanoparticles, metal plasmonic nanoparticles, biomolecular layers, and live cells. Because PCEM does not require cytotoxic stains or photobleachable fluorescent dyes, it is especially useful for monitoring the long-term interactions of cells with extracellular matrix surfaces. PCEM is only sensitive to the attachment of cell components within ~200 nm of the photonic crystal surface, which may correspond to the region of most interest for adhesion processes that involve stem cell differentiation, chemotaxis, and metastasis. PCEM has also demonstrated sufficient sensitivity for sensing nanoparticle contrast agents that are roughly the same size as protein molecules, which may enable applications in "digital" diagnostics with single molecule sensing resolution. We will review PCEM's devel...Continue Reading

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Citations

Apr 5, 2017·ACS Applied Materials & Interfaces·Delong WangXiangwei Zhao
Oct 25, 2016·Trends in Biotechnology·ShuQi WangUtkan Demirci
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Nov 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Tahmid H TalukdarJudson D Ryckman
May 28, 2019·ACS Sensors·Jiawei WangOliver G Schmidt

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Methods Mentioned

BETA
biosensing
biosensor
AFM
biosensors
imaging techniques
fluorescence imaging
affinity capture
atomic force microscopy
surface plasmon resonance
Fluorescence

Software Mentioned

MathWorks
Matlab
BIND Scanner

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