Label free sensing of creatinine using a 6 GHz CMOS near-field dielectric immunosensor

The Analyst
S GuhaCh Wenger

Abstract

In this work we present a CMOS high frequency direct immunosensor operating at 6 GHz (C-band) for label free determination of creatinine. The sensor is fabricated in standard 0.13 μm SiGe:C BiCMOS process. The report also demonstrates the ability to immobilize creatinine molecules on a Si3N4 passivation layer of the standard BiCMOS/CMOS process, therefore, evading any further need of cumbersome post processing of the fabricated sensor chip. The sensor is based on capacitive detection of the amount of non-creatinine bound antibodies binding to an immobilized creatinine layer on the passivated sensor. The chip bound antibody amount in turn corresponds indirectly to the creatinine concentration used in the incubation phase. The determination of creatinine in the concentration range of 0.88-880 μM is successfully demonstrated in this work. A sensitivity of 35 MHz/10 fold increase in creatinine concentration (during incubation) at the centre frequency of 6 GHz is gained by the immunosensor. The results are compared with a standard optical measurement technique and the dynamic range and sensitivity is of the order of the established optical indication technique. The C-band immunosensor chip comprising an area of 0.3 mm(2) reduces the...Continue Reading

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Feb 28, 2014·ACS Nano·Steve FengAydogan Ozcan

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Citations

Sep 24, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·M BirkholzR Scholz
Sep 28, 2017·Biosensors·Subhajit GuhaChristian Wenger
Jun 15, 2019·Biosensors·Honeyeh Matbaechi EttehadChristian Wenger

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