Label-free SERS detection of relevant bioanalytes on silver-coated carbon nanotubes: The case of cocaine

Nanoscale
Marcos Sanles-SobridoLuis M Liz-Marzán

Abstract

Surface-enhanced Raman scattering (SERS) spectroscopy can be used for the label-free determination and quantification of relevant small biometabolites that are hard to identify by conventional immunological methods, in the absence of labelling. In this work, detection is based on monitoring the vibrational changes occurring at a specific biointerface (a monoclonal antibody, mAb) supported on silver-coated carbon nanotubes (CNT@Ag). Engineered CNT@Ag play a key role, as they offer a stable substrate to support the biointerface, with a high density of hot spots. Proof of concept is demonstrated through the analysis and quantification of the main cocaine metabolite benzoylecgonine. These results open a new avenue toward the generation of portable sensors for fast ultradetection and quantification of relevant metabolites. The use of discrete particles (CNT@Ag@mAb) rather than rough films, or other conventional SERS supports, will also enable a safe remote interrogation of highly toxic sources in environmental problems or in biological fluids.

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Citations

Mar 29, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Rafael Contreras-CáceresLuis M Liz-Marzán
May 14, 2010·Journal of the Royal Society, Interface·Sara Abalde-CelaLuis M Liz-Marzán
Jul 8, 2011·Nanoscale·Nicolas Pazos-PerezRamon A Alvarez-Puebla
Dec 8, 2015·Analytical Chemistry·Cyril MuehlethalerJohn R Lombardi
Sep 4, 2012·Analytica Chimica Acta·Laura Rodriguez-LorenzoRamon A Alvarez-Puebla
Aug 15, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Alfonso MartínDaniela Iacopino
Jun 11, 2014·Scientific Reports·Jean-Christophe ValmaletteSatoshi Ohara
Oct 18, 2012·Angewandte Chemie·Ramón A Alvarez-Puebla, Luis M Liz-Marzán
Jul 28, 2012·Advanced Materials·Seunghyun LeeJason H Hafner
Jan 29, 2010·Small·Ramón A Alvarez-Puebla, Luis M Liz-Marzán
Sep 22, 2009·Chemistry, an Asian Journal·Shuhua Liu, Ming-Yong Han
Dec 6, 2014·ChemistryOpen·Andrea La PortaLuis M Liz-Marzán
Feb 22, 2012·Analytica Chimica Acta·Jinwen ZhouNicolas H Voelcker
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Aug 6, 2011·Chemical Society Reviews·Ramon A Alvarez-Puebla, Luis M Liz-Marzán
Nov 11, 2011·Nanoscale·Rolando Pérez-PineiroRamon A Alvarez-Puebla
Nov 28, 2018·Sensors·Riikka PeltomaaMaría C Moreno-Bondi
Feb 6, 2018·Reviews in Analytical Chemistry·Anh H NguyenZachary D Schultz
Sep 4, 2019·ACS Nano·Judith LangerLuis M Liz-Marzán
Mar 16, 2017·ACS Nano·Beatriz PelazWolfgang J Parak
Aug 23, 2018·ACS Applied Materials & Interfaces·Victoria M SzlagChristy L Haynes

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