Abstract
Zirconium molybdate gel was prepared by mixing (99)Mo, produced from (98)Mo(n,gamma) reaction and Zr solutions in nitrate media with excess H(2)O(2), and used as the base material for (99)Mo/(99m)Tc generator. The prepared generator showed a good performance. (99m)Tc eluted from the prepared generator passed the quality control tests with specifications meeting the requirements of European and US Pharmacopeias. The (99m)Tc eluate was used for labeling of cephalosporin analogue, ceftriaxone, which was then assessed for infection imaging in a mouse model. (99m)Tc-ceftriaxone was prepared at pH 9 with a radiochemical yield of 95+/-2% by adding (99m)Tc to 30 mg ceftriaxone in the presence of 50 microg SnCl(2).2H(2)O. Biodistribution studies in mice were carried out using experimentally induced infection in the left thigh using E. coli. Both thighs of the mice were dissected and counted to evaluate the ratio of bacterial infected thigh/contralateral thigh. (99m)Tc-ceftriaxone showed high uptake in the infectious lesion (T/NT =5.6+/-0.6 at 4h post injection). The abscess to normal muscle ratio indicated that (99m)Tc-ceftriaxone could be used for infection imaging. Besides, in vitro studies showed that (99m)Tc-ceftriaxone can differen...Continue Reading
References
Jan 1, 1987·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·J V EvansJ M Sodeau
Oct 1, 1983·European Journal of Clinical Microbiology·W M Scheld
Jul 18, 2000·Antimicrobial Agents and Chemotherapy·B FournierD C Hooper
Sep 6, 2000·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·M AsikogluH Ozkilic
Apr 13, 2004·American Heart Journal·George M Eliopoulos
Apr 20, 2004·Nuclear Medicine Communications·Filip GemmelRudi A Dierckx
Jul 31, 2009·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·M R DavarpanahM Ghannadi Maragheh
Nov 11, 2009·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Sankha ChattopadhyayShantanu Ganguly
Citations
May 26, 2012·Pharmacology & Therapeutics·D A DorwardK Dhaliwal
Jan 25, 2011·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Syed Qaiser Shah, Muhammad Rafiullah Khan
Sep 27, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Muhammad SohaibSamina Roohi
Aug 12, 2016·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·S AulettaAlberto Signore
Aug 23, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Torsten KniessJens Pietzsch
Jun 13, 2018·Cancer Biotherapy & Radiopharmaceuticals·Mohamed H AboumaneiMohamed T El-Kolaly
Nov 22, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Derya Ïlem-ÖzdemirSemin Ayhan
Feb 18, 2016·Journal of Labelled Compounds & Radiopharmaceuticals·Derya Ilem-OzdemirSemin Ayhan
Feb 10, 2017·Journal of Labelled Compounds & Radiopharmaceuticals·Rashid RasheedNidda Saeed
Nov 23, 2019·International Journal of Molecular Sciences·Justin D NorthrupMark A Sellmyer
Mar 2, 2021·Nuclear Medicine and Molecular Imaging·Sae-Ryung Kang, Jung-Joon Min
Mar 7, 2021·Pharmaceuticals·Qing RuanJunbo Zhang
Feb 18, 2018·Seminars in Nuclear Medicine·Alvaro A Ordonez, Sanjay K Jain
Sep 30, 2020·Bioorganic & Medicinal Chemistry·Hanan Gaber AbdulwahabHeba S A El-Zahabi
Apr 28, 2021·Biopharmaceutics & Drug Disposition·Kubra DurkanFatma Yurt
Nov 10, 2013·Bioconjugate Chemistry·A BunschotenF W B van Leeuwen
Jul 16, 2021·Chemical Biology & Drug Design·Syed Ali Raza Naqvi