Labetalol, nebivolol, and propranolol relax human radial artery used as coronary bypass graft

The Journal of Thoracic and Cardiovascular Surgery
Ozge KorkmazIhsan Bagcivan

Abstract

Beta-blockers are a heterogeneous class of agents that are used in the treatment of many cardiovascular diseases, especially hypertension and atherosclerosis, and that are commonly prescribed after cardiac surgery. In the present study, the aim is to investigate the vasorelaxant effects of some common beta-adrenoceptor blockers on the human radial artery in vitro, as well as their relaxation mechanisms. Radial artery rings sourced from human patients were mounted in an organ bath and tested for changes in isometric tension in relaxation response to labetalol, nebivolol, and propranolol in the presence and absence of NG-nitro-L-arginine methyl ester (3 × 10(-5) mol/L) and tetraethyl ammonium (3 × 10(-4) mol/L). The labetalol (10(-8) to 10(-4) mol/L), nebivolol (10(-8) to 10(-4) mol/L), and propranolol (10(-8) to 10(-4) mol/L) induced concentration-dependent relaxations on the radial artery rings, which had been precontracted with phenylephrine (10(-6) mol/L). The relaxation response induced by labetalol in the isolated radial artery rings was significantly higher when compared with the nebivolol and propranolol samples (P < .05). NG-nitro-L-arginine methyl ester significantly reduced the relaxation of nebivolol (P < .05), and te...Continue Reading

References

Oct 1, 1992·The Annals of Thoracic Surgery·C AcarJ L Guermonprez
Dec 2, 1998·The Journal of Thoracic and Cardiovascular Surgery·C AcarA Carpentier
Feb 1, 2005·European Journal of Pharmacology·Adriana GeorgescuDoina Popov
Nov 26, 2013·The Journal of Thoracic and Cardiovascular Surgery·Miklos D KertaiUNKNOWN Cardiothoracic Anesthesia Research Endeavors (CARE) Group
Dec 7, 2013·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E BayarM E Durakoglugil
Apr 4, 2014·Advances in Pharmacological Sciences·Candice PullenAndrew Fenning
Apr 23, 2014·The Canadian Journal of Cardiology·Pierre LarochelleYves Lacourcière

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Citations

Feb 11, 2015·The Journal of Thoracic and Cardiovascular Surgery·Alden H Harken
Aug 6, 2016·Journal of the American College of Cardiology·Marc Ruel, Pierre Voisine
Aug 10, 2017·The Journal of Thoracic and Cardiovascular Surgery·Devendra K Agrawal, Chandra S Boosani

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