PMID: 9170463Jun 1, 1997Paper

Labor induction with intravaginal misoprostol in term premature rupture of membranes: a randomized study

Obstetrics and Gynecology
L Sanchez-RamosI Delke

Abstract

To evaluate the safety and clinical effectiveness of intravaginal misoprostol, a synthetic prostaglandin E1 analogue, for labor induction in gravidas with premature rupture of membranes (PROM) at term. One hundred forty-one pregnant women with term PROM were assigned randomly to one of two induction groups: 1) intravaginal misoprostol or 2) intravenous oxytocin by continuous infusion. Seventy subjects were allocated to the misoprostol group and 71 to the oxytocin group. The mean (+/- standard deviation) interval from induction to delivery was significantly shorter in the misoprostol group (416 +/- 276 compared with 539 +/- 372 minutes; P = .04). In 85.7% of patients in the misoprostol group, only one dose was required. Intrapartum complication rates, mode of delivery, and neonatal or maternal adverse event rates were similar in the two treatment groups. Uterine tachysystole occurred more frequently with misoprostol than with oxytocin (28.6% compared with 14.0%; P < .04). Intravaginal administration of misoprostol induces labor safely and effectively in patients with PROM at term.

Associated Clinical Trials

References

Jun 1, 1978·Clinical Obstetrics and Gynecology·W E Fuller
Jan 1, 1992·American Journal of Perinatology·J M GuiseJ S Christian
Jun 1, 1995·American Journal of Obstetrics and Gynecology·D A WingR H Paul
Nov 1, 1993·Acta Obstetricia Et Gynecologica Scandinavica·L S SperlingB Ploug-Jensen
Jul 1, 1993·British Journal of Obstetrics and Gynaecology·H M FletcherD Brown
Jun 1, 1996·Obstetrics and Gynecology·S W NgaiP C Ho

❮ Previous
Next ❯

Citations

Feb 28, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R A HoffmannS Fawcus
Dec 1, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·W M Hern
May 29, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S OzdenC Fiçicioglu
Jan 30, 2002·Obstetrics and Gynecology·Kelly BlanchardCaitlin Shannon
Sep 13, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M Mutlu MeydanliAli Haberal
Sep 16, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Joan M G Crane, David C Young
Jan 4, 2001·The New England Journal of Medicine·A B GoldbergP D Darney
Dec 29, 2000·Current Opinion in Obstetrics & Gynecology·P S RamseyS M Ramin
Nov 26, 1999·Clinical Obstetrics and Gynecology·E Mozurkewich
Aug 19, 2000·Clinical Obstetrics and Gynecology·L Sanchez-Ramos, A M Kaunitz
Aug 19, 2000·Clinical Obstetrics and Gynecology·H Hadi
Aug 4, 2006·Clinical Obstetrics and Gynecology·Deborah A Wing, Cecilia A Lyons Gaffaney
Aug 4, 2006·Clinical Obstetrics and Gynecology·Ellen Mozurkewich
Jan 31, 2004·Obstetrical & Gynecological Survey·Yap-Seng ChongSabaratnam Arulkumaran
Oct 8, 1998·British Journal of Obstetrics and Gynaecology·A Templeton
May 27, 2005·The Journal of Obstetrics and Gynaecology Research·Yuthika SharmaVatsla Dadhwal
Aug 17, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Fabiana da Graça KrupaMary Angela Parpinelli
Aug 30, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·L BrickerZ Alfirevic
Jun 7, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sahin ZeteroğluMansur Kamaci
Oct 20, 2001·American Journal of Obstetrics and Gynecology·H Y HowB M Sibai
Oct 4, 2003·American Journal of Obstetrics and Gynecology·Joan M G CraneDonna Hutchens
Aug 24, 1999·American Journal of Obstetrics and Gynecology·D A Wing
May 10, 2017·American Journal of Obstetrics and Gynecology·Jennifer M H AmorosaAngela Bianco
Oct 12, 2010·The Cochrane Database of Systematic Reviews·G Justus HofmeyrCynthia Pileggi
Sep 2, 2005·Obstetrics and Gynecology·Monique G LinPatrick S Ramsey
Jul 18, 2003·Journal of Midwifery & Women's Health·Alisa B Goldberg, Deborah A Wing
Jul 26, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Deborah A Wing
Oct 9, 2002·Obstetrical & Gynecological Survey·William F Rayburn
Jun 20, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·L Haghighi
Nov 2, 2019·Gynécologie, Obstétrique, Fertilité & Sénologie·A Girault

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.