Laboratory-acquired lethal infections by potential bioweapons pathogens including Ebola in 2014

FEMS Microbiology Letters
Simon Silver

Abstract

Researchers studying both cellular and viral disease agents in the laboratory have become infected since the early days of microbiology 150 years ago. However, in the early 21st century, new concerns about bioweapons being used to generate terror and also with a series of newly emerging or newly understood disease-causing microbes have resulted in infections and deaths of workers studying these microbes in the laboratory, generally to gain understanding and to develop treatments and vaccines. Here, five examples are summarized: (i) smallpox virus escaped from a UK laboratory where it was being maintained and stored, (ii) the 2014 infections and deaths of five researchers who were isolating West African Ebola virus for DNA sequencing epidemiology studies, (iii) and (iv) two recent infections that happened in the same US laboratory where researchers were infected with agents causing septicemic Yersinia plague and Bacillus anthrax and (v) the 2012 death in California from laboratory infection by Neisseria meningitidis resulting in spinal meningitis.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J ChouS N Cohen
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M J Casadaban
Jun 1, 1969·Journal of Bacteriology·R R Brubaker
Nov 18, 1994·Science·M MeselsonO Yampolskaya
Sep 9, 1999·The New England Journal of Medicine·T C DixonP C Hanna
Dec 19, 2001·Emerging Infectious Diseases·J A JerniganUNKNOWN Anthrax Bioterrorism Investigation Team
Jan 31, 2003·The New England Journal of Medicine·Joel G BremanFrank Fenner
Jan 1, 1955·Annual Review of Microbiology·G GIRARD
Sep 8, 2005·Journal of Clinical Microbiology·James J SejvarNancy E Rosenstein
Sep 27, 2005·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·Bradley T SmithTara O'Toole
May 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Nicholas J VietriArthur M Friedlander
Jun 2, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kamaljit Singh
Jun 1, 2010·Journal of Bacteriology
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·David A RaskoJacques Ravel
Jul 1, 2011·The New England Journal of Medicine·Karen M FrankWun-Ju Shieh
Oct 19, 2011·The Journal of Infectious Diseases·Stephan GüntherStefan Schmiedel
Aug 17, 2012·The Journal of Infectious Diseases·Lauriane E QueneeOlaf Schneewind
Jan 16, 2013·Infection and Immunity·So-Young OhOlaf Schneewind
Oct 5, 2013·Genome Announcements·Géraldine A Van der AuweraJacques Mahillon
Nov 29, 2013·Conservation Biology : the Journal of the Society for Conservation Biology·Michael J FosterEleanor J Sterling
Aug 30, 2014·Science·Isao Arita, Donald Francis

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