Laboratory and animal model evaluation of the Cryotech LCS 2000 in hepatic cryotherapy

Cryobiology
A V DilleyD L Morris

Abstract

Hepatic cryotherapy is increasingly used in the treatment of patients with multiple hepatic metastases, particularly from colorectal cancer. The Cryotech LCS 2000 system, with insulated shaft-circulated liquid nitrogen probes, was designed for this purpose and was evaluated on the bench and in an animal model. The 9-mm probe was considerably more effective than the 5-mm probe when judged on time to create an iceball of a given diameter. The use of thawing gas reduced the time until the probe could be removed from 25 to 5 min but heated gas only produced a further reduction of 2 min. In the animal model, significant reduction in treatment times occurred with vascular inflow occlusion. The zone of necrosis as a percentage of the original iceball diameter was significantly higher following a twin freeze/thaw cycle. The relationship of the edge of the iceball to the eventual zone of hepatic necrosis was studied using different unabsorbable markers. India ink and sutures proved unreliable but a Teflon cannula was more successful and the margin was only of the order of 2 mm. The discrepancy between this observation and the percentage of the original iceball diameter which apparently becomes necrotic (64 and 82%) for single- and doubl...Continue Reading

Citations

Apr 1, 1999·The British Journal of Surgery·J K Seifert, D L Morris
Aug 26, 1998·Annals of Surgery·J K Seifert, D L Morris
May 1, 1997·Australasian Radiology·J KingD L Morris
Jan 15, 2004·IEEE Transactions on Medical Imaging·Romain FournialChristian Moisan
Apr 3, 2004·Technology in Cancer Research & Treatment·Bumsoo HanJohn C Bischof
Oct 8, 1998·Journal of Surgical Oncology·P S SoonD L Morris
Mar 11, 1998·Seminars in Surgical Oncology·K Littlewood
Feb 21, 2003·The British Journal of Surgery·C Erce, R W Parks
Apr 22, 1999·Diseases of the Colon and Rectum·J K Seifert, D L Morris
May 12, 2006·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Tom Mala
Apr 15, 2003·Current Opinion in Urology·Patrick S Lowry, Stephen Y Nakada

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