PMID: 9423220Jan 10, 1998Paper

Laboratory assays for von Willebrand factor: relative contribution to the diagnosis of von Willebrand's disease

Pathology
Emmanuel J Favaloro, J Koutts

Abstract

Appropriate investigation of a patient with suspected von Willebrand's disease (VWD) involves a clinical assessment of the patient followed by laboratory testing. A variety of laboratory assays may be performed, not necessarily restricted to an assessment of von Willebrand factor (VWF). Due to the limitations of each assay, and because of VWD heterogeneity, no single test procedure is sufficiently robust to permit detection of all VWD variants. Indeed, these factors often lead to considerable confusion in the process of laboratory interpretation regarding the likelihood of VWD, and the subtype of VWD. This paper attempts to clarify some of the issues that lead to this confusion. It analyses the relative contribution of four separate assays for VWF [VWF:Multimer analysis, VWF:Antigen (VWF:Ag), VWF:Ristocetin Cofactor (VWF:RCof), and VWF:Collagen Binding Activity assay (VWF:CBA)] to the diagnosis and classification of VWD. Although each assay detects VWF, it is important to recognise that each assay provides different information on the VWF so detected. For example, while the VWF:Ag assay is a quantitative assay and provides a very good measure of the overall level of VWF present in a patient's plasma, it is not a functional assa...Continue Reading

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Citations

Oct 20, 2004·American Journal of Clinical Pathology·Emmanuel J FavaloroJane McDonald
Jun 21, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Muriel MeiringMareli Kelderman
Feb 4, 2006·American Journal of Veterinary Research·Elizabeth Peet SabinoJames L Catalfamo
Jan 2, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·E J FavaloroUNKNOWN Australasian Society for Thrombosis and Haemostasis (ASTH) Emerging Technologies Group
Feb 25, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Filippo MoriClaudio Farina
Jun 11, 2014·Thrombosis Research·Emmanuel J FavaloroKatherine Marsden
May 1, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·A ViswabandyaA Srivastava
Jun 21, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·T BurnoufM El-Ekiaby
Dec 14, 1999·The Journal of Laboratory and Clinical Medicine·C BironJ F Schved
Apr 11, 2015·Journal of Thrombosis and Haemostasis : JTH·I BodóUNKNOWN von Willebrand factor Subcommittee of the Standardization and Scientific Committee of the International Society for Thrombos
Oct 2, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Anwar M Al-AwadhiSeham K Al-Sharrah
Jan 18, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·M BowmanP James
Mar 22, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·E J FavaloroJ Koutts
Sep 9, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Christoph SuckerRainer B Zotz
Aug 27, 2010·Circulation. Heart Failure·Anna L MeyerMartin Strueber
Jun 22, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·An De Vleeschauwer, Katrien Devreese
Dec 26, 2018·Circulation Research·Vanessa H BraitAnna M Planas
Apr 14, 2007·World Journal of Surgery·Anita Dhar, Anurag Srivastava
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·P A Kouides
May 1, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Ingerslev, T Gürsel
Apr 1, 2002·Paediatrics & Child Health·Robert J Klaassen, Jacqueline M Halton
Dec 29, 2016·Progress in Retinal and Eye Research·Teresia CarreonSanjoy K Bhattacharya

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