Laboratory Biomarkers, Cerebral Blood Flow Velocity, and Intellectual Function in Children with Sickle Cell Disease

Advances in Hematology
Nataly ApollonskyReem Tarazi

Abstract

The aim of this preliminary study was to describe putative markers of cerebral vasculopathy and investigate relationships among these markers, demographic factors, and cognitive function in a young sample of neurologically normal children with SCD. Study Design. Thirty-eight children with homozygous HbS, aged 4-11 years, were included. Estimated IQ and markers of coagulation and endothelial activation, hemolysis, and inflammation, as well as transcranial Doppler velocities, hydroxyurea use, and demographic information were obtained. Using multiple regression analyses, there were few significant independent associations between biomarkers or blood flow velocity and estimated IQ. Lactic dehydrogenase (LDH) independently predicted cognitive function, but blood flow velocity did not mediate this relationship. Maternal education, patient age, and hydroxyurea status were independent predictors of cognition. Given the small sample size, a LASSO statistical model was employed to further identify potential predictors of IQ, which identified LDH, absolute neutrophil count (ANC), platelet count, thrombin-antithrombin (TAT), tissue factor (TF), maternal education, age, and hydroxyurea as potential predictors of cognition. In addition to ef...Continue Reading

References

Sep 20, 2001·The Journal of Pediatrics·W WangUNKNOWN Cooperative Study of Sickle Cell Disease
Mar 23, 2002·Journal of Pediatric Psychology·Robert J ThompsonRussell E Ware
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Mar 17, 2007·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Eve PufferCarla W Roberts
May 13, 2010·JAMA : the Journal of the American Medical Association·Elliott P VichinskyUNKNOWN Neuropsychological Dysfunction and Neuroimaging Adult Sickle Cell Anemia Study Group
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Citations

Mar 12, 2021·Journal of Pediatric Psychology·Reem A TaraziNataly Apollonsky
Aug 1, 2021·Pediatric Blood & Cancer·Winfred C WangJane S Hankins

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Methods Mentioned

BETA
blood draw
enzyme-linked immunosorbent assay
PCA

Software Mentioned

LASSO
R
SPSS

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