Laboratory characterization of invasive Haemophilus influenzae isolates from Nunavut, Canada, 2000-2012

International Journal of Circumpolar Health
Raymond S W TsangJohn Spika

Abstract

With invasive Haemophilus influenzae serotype b (Hib) disease controlled by vaccination with conjugate Hib vaccines, there is concern that invasive disease due to non-serotype b strains may emerge. This study characterized invasive H. influenzae (Hi) isolates from Nunavut, Canada, in the post-Hib vaccine era. Invasive H. influenzae isolates were identified by conventional methods at local hospitals; and further characterized at the provincial and federal public health laboratories, including detection of serotype antigens and genes, multi-locus sequence typing and antibiotic susceptibility. Of the 89 invasive H. influenzae cases identified from 2000 to 2012, 71 case isolates were available for study. There were 43 serotype a (Hia), 12 Hib, 2 Hic, 1 Hid, 1 Hie, 2 Hif and 10 were non-typeable (NT). All 43 Hia were biotype II, sequence type (ST)-23. Three related STs were found among the Hib isolates: ST-95 (n=9), ST-635 (n=2) and ST-44 (n=1). Both Hif belonged to ST-124 and the 2 Hic were typed as ST-9. The remaining Hid (ST-1288) and Hie (ST-18) belonged to 2 separate clones. Of the 10 NT strains, 3 were typed as ST-23 and the remaining 7 isolates each belonged to a unique ST. Eight Hib and 1 NT-Hi were found to be resistant to ...Continue Reading

References

Apr 7, 2006·Journal of Clinical Microbiology·Raymond S W TsangDennis K S Law
Mar 31, 1931·The Journal of Experimental Medicine·M Pittman
Feb 25, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey M BenderAndrew T Pavia
Oct 16, 2014·Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada·S DesaiA Cox

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Citations

Feb 25, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Raymond S W TsangDorothy Moore
Jan 21, 2017·Genome Announcements·Mariam IskanderRaymond Tsang
Aug 2, 2019·Journal of Medical Microbiology·Tadashi HoshinoNaruhiko Ishiwada
Jun 27, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Heidi M SoetersMichael G Bruce
Jun 27, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marina Ulanova
May 18, 2018·Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada·A D CoxUNKNOWN Conference contributors
Feb 22, 2017·Emerging Infectious Diseases·Robert WhittakerUNKNOWN European Centre for Disease Prevention and Control Country Experts for Invasive Haemophilus influenzae Disease
Mar 29, 2021·The Journal of Infection·Nora ChekrouniDiederik van de Beek

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Methods Mentioned

BETA
biotyping
PCR
electrophoresis

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