PMID: 16634372Apr 26, 2006Paper

Laboratory diagnosis and management challenges in the antiphospholipid syndrome

Lupus
M L Bertolaccini, M A Khamashta

Abstract

The antiphospholipid syndrome (APS) is characterized by recurrent arterial and/or venous thrombosis and pregnancy morbidity manifested by early or late losses. Laboratory diagnosis ofAPS relies on the demonstration of a positive test for antiphospholipid antibodies (aPL). In clinical practice, the gold standard tests are those that detect anticardiolipin antibodies (aCL) and/or the lupus anticoagulant (LA). Although other specificities for aPL have been described their clinical utility and standardization has still to be established. Persistence of aPL positive tests must be demonstrated, and other causes and underlying factors considered. Although it is universally recognized that the routine screening tests (aCL and/or LA) might miss some cases, careful differential diagnosis and repeat testing are mandatory before the diagnosis of 'seronegative APS' can be made. Correct identification of patients with APS is important, because prophylactic anticoagulant therapy can prevent thrombosis from recurring, and treatment of affected women during pregnancy can improve fetal and maternal outcome.

References

Dec 15, 1992·Annals of Internal Medicine·K S GinsburgM J Stampfer
Aug 15, 1992·Annals of Internal Medicine·M H Rosove, P M Brewer
Jan 22, 1988·JAMA : the Journal of the American Medical Association·D A TriplettC A Orr
Jan 1, 1987·Annals of the Rheumatic Diseases·A E GharaviG R Hughes
Oct 15, 1983·British Medical Journal·G R Hughes
Apr 13, 1995·The New England Journal of Medicine·M A KhamashtaG R Hughes
Jul 17, 1997·The New England Journal of Medicine·J H RandP C Harpel
Aug 6, 2000·British Journal of Haematology·M GreavesI Mackie
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K K HwangP P Chen
Mar 8, 2002·The New England Journal of Medicine·Jerrold S LevineJoyce Rauch
Apr 16, 2002·Arthritis and Rheumatism·Ricard CerveraUNKNOWN Euro-Phospholipid Project Group

❮ Previous
Next ❯

Citations

Nov 18, 2008·The Journal of Perinatal & Neonatal Nursing·Susan MathewLene Symes
Nov 14, 2006·Current Opinion in Obstetrics & Gynecology·Yair Molad
Jan 18, 2014·Forensic Science, Medicine, and Pathology·Bartosz HudzikLech Polonski
Apr 18, 2009·Rheumatology International·Daniel AthanazioMittermayer Barreto Santiago
Jan 12, 2008·Chest·Jeffrey J SwigrisKevin K Brown
Oct 24, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Haifeng WuLee A Hebert
Nov 26, 2010·Medicina clínica·Andrés Felipe Lopera-Vallejo, Jaume Alijotas-Reig
Oct 23, 2010·Revue des maladies respiratoires·D CarmierE Diot
Mar 22, 2007·Actas dermo-sifiliográficas·C García-García
Dec 25, 2008·Revue des maladies respiratoires·D CarmierE Diot
Apr 1, 2008·La Revue de médecine interne·A Duval, J Pouchot
Sep 18, 2009·Annals of the New York Academy of Sciences·Cristiano AlessandriGuido Valesini
May 1, 2008·Alcoholism, Clinical and Experimental Research·Antti E NissinenMarkku J Savolainen
Jan 20, 2009·World Journal of Gastroenterology : WJG·Kamran AhmedIraklis E Katsoulis
Jan 3, 2013·Hemodialysis International·O Susan IheagwaraSusie Q Lew
Jul 19, 2008·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Silas W SmithRobert S Hoffman
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yao-Hsu YangPojen P Chen
Nov 2, 2019·Multiple Sclerosis and Related Disorders·Paula WildnerMariola Matysiak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.