PMID: 6987923Feb 1, 1980Paper

Laboratory diagnosis of Legionnaires' disease

The American Review of Respiratory Disease
P H EdelsteinS M Finegold

Abstract

Legionnaires' disease was diagnosed in 32 patients with nosocomially acquired pneumonia by using direct immunofluorescence examination of respiratory tract secretions, indirect immunofluorescence determinations of antibody titer, and/or culture of Legionella pneumophila from respiratory tract secretions. Cultures of specimens for Legionella pneumophila were positive for 13 of 21 patients for whom appropriate specimens were submitted. Using a positive culture as a definition of Legionnaires' disease, the sensitivity of direct immunofluorescence examination was 62%; that of indirect immunofluorescence serologic studies, 75%. Using any positive test as a definition of Legionnaires' disease, the sensitivity of direct immunofluorescence examination of respiratory tract secretions was 50%, that of indirect immunofluorescence serologic studies (using all 4 serogroups), 80%; that of culture, 65%. A negative control group of 21 patients without Legionnaires' disease was used to estimate the specificity of the tests. The specificity of direct immunofluorescence examination was 94%; that of indirect immunofluorescence serologic studies, 75%. Culture of specimens was necessary to diagnose some cases of Legionnaires' disease because the oth...Continue Reading

Citations

Sep 1, 1989·Irish Journal of Medical Science·R HoneJ Hollingsworth
Feb 1, 1981·The American Journal of Medicine·D W Fraser
Dec 1, 1980·The Practitioner·A J Spicer
Feb 26, 2004·Paediatric Respiratory Reviews·Bernard La Scola, Helen Maltezou
Apr 1, 1996·Epidemiology and Infection·J C BellA G Capon
Dec 1, 1985·Antimicrobial Agents and Chemotherapy·A W PasculleM A Levi
Feb 1, 1987·Journal of Clinical Pathology·J M TheakerK A Fleming
Nov 1, 1989·The Journal of Infection·K BartonT S Wilson
Nov 7, 1981·British Medical Journal·J T MacfarlaneA D Macrae
Feb 16, 1991·BMJ : British Medical Journal·R S BhopalJ D Urquhart

Related Concepts

Antibodies, Bacterial
Bacteriological Techniques
Enzyme-Linked Immunosorbent Assay
Immunofluorescence Assay
Legionnaires' Disease
Sputum, Induced

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