Laboratory diagnostics of invasive fungal infections: an overview with emphasis on molecular approach.

Folia Microbiologica
L Bašková, Vladimír Buchta

Abstract

Although invasive fungal diseases (IFDs) are relatively rare, they have become an increasingly common life-threatening complication in a variety of critically ill patients. Due to changes in treatment strategies, patterns of IFDs have changed substantially as well. Yeast infections have shifted toward a higher proportion of non-albicans Candida species, but their overall incidence has remained stable. In contrast, IFDs caused by molds, including particularly various species of Aspergillus, Fusarium, and Mucorales, have increased in number. In view of the growing incidence and the high mortality rates of IFDs, accurate diagnostic techniques permitting timely onset of adequate antifungal treatment are of paramount importance. Although conventional approaches such as microscopy, cultivation, histopathological examination, and imaging methods still represent the gold standard, the diagnosis remains difficult because of limited sensitivity and specificity. Noninvasive and culture-independent diagnostic techniques, including fungal antigen detection, and different molecular-based techniques are becoming increasingly important. Of the fungal surrogate markers such as cell wall components, galactomannan and (1,3)-β-D-glucan by commerci...Continue Reading

References

Jan 1, 1994·Journal of Clinical Microbiology·A R HolmesH F Jenkinson
Aug 1, 1996·Journal of Clinical Microbiology·K MitsutakeS Kohno
Jun 13, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D W Denning
Mar 13, 1999·Medical Mycology·J LöfflerH Einsele
Apr 17, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J W BaddleyP G Pappas
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Raoul HerbrechtErmanno Candolfi
Apr 4, 2002·The Journal of Infectious Diseases·Juergen LoefflerHermann Einsele
Jul 5, 2002·Clinical Microbiology Reviews·Siew Fah Yeo, Brian Wong
Dec 19, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·B D Alexander
Dec 5, 2003·Lancet·Michail S Lionakis, Dimitrios P Kontoyiannis
Mar 5, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claudio ViscoliAndrea Bacigalupo
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zekaver OdabasiLuis Ostrosky-Zeichner
Feb 9, 2005·Diagnostic Microbiology and Infectious Disease·Maura PrellaOscar Marchetti
Aug 5, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luis Ostrosky-ZeichnerJohn H Rex
Oct 7, 2005·Journal of Clinical Microbiology·David N FredricksAmalia Meier
Nov 8, 2005·Journal of Clinical Microbiology·Spinello AntinoriCarlo Parravicini
Dec 8, 2005·Journal of Clinical Microbiology·Jerry W PickeringGail L Woods
Mar 7, 2006·Journal of Clinical Microbiology·Shiang Ning LeawTsung Chain Chang
Sep 21, 2006·Infectious Disease Clinics of North America·Monique A S H Mennink-Kersten, Paul E Verweij
Sep 29, 2006·Antimicrobial Agents and Chemotherapy·Francisco M MartyLindsey R Baden
Mar 17, 2007·Medical Mycology·D H PincusS Chatellier
Apr 17, 2007·American Journal of Infection Control·Renato C CoutoFernando M Biscione
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johan A MaertensPaul E Verweij
Aug 24, 2007·Journal of Clinical Microbiology·Birgit SpiessDieter Buchheidt
Nov 15, 2007·Current Infectious Disease Reports·L Joseph Wheat
Jan 8, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas J WalshUNKNOWN Infectious Diseases Society of America
Apr 24, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Richardson, C Lass-Flörl
Apr 24, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H Einsele, J Loeffler

❮ Previous
Next ❯

Citations

Oct 21, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Ag DeepaAnna P Joseph
Jul 23, 2016·The Laryngoscope·Peter G Volsky, Todd A Hillman
Apr 15, 2014·European Biophysics Journal : EBJ·Sarah R DennisonDavid A Phoenix
Oct 19, 2013·Expert Review of Anti-infective Therapy·Kim VanstraelenIsabel Spriet
Jun 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gururaj C AithalSanjay Garg
Apr 4, 2020·Medical Mycology·Richard KwizeraRobert Lukande

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.