Laboratory evaluation of a potential diesel fuel interference in the determination of polycyclic aromatic compounds on dermal samplers

Journal of Occupational and Environmental Hygiene
Robert A WekerRichard D Rinehart

Abstract

Road pavers are exposed to asphalt fumes through dermal contact, inhalation, or ingestion. These fumes contain polycyclic aromatic compounds (PACs), a class of compounds including polycyclic aromatic hydrocarbons (PAHs). The PAHs include compounds such as pyrene and benzo(a)pyrene and a large number of other compounds of known or suspected carcinogenicity. To estimate dermal deposition of asphalt fume particulate matter, polypropylene sampling patches can be worn on a worker's inside wrist. Diesel fuel used for cleaning can splash onto the dermal sampler. Exposed dermal patches were solvent extracted and PACs estimated in the extract using a modification of NIOSH Method 5800. The final solution was analyzed by high pressure liquid chromatography (HPLC) with a fluorescence detector using an excitation wavelength of 270 nanometers and an emission wavelength of 415 nanometers. The PACs were concentrated on a C-18 reverse phase guard column but not separated so that they could be measured expediently as a group. In this study we examined whether deposited diesel fuel interferes with the HPLC determination of PACs. We characterized the effect of diesel fuel contamination over broad ranges of both analyte and interferent. Two drops, ...Continue Reading

References

Jul 1, 1993·British Journal of Industrial Medicine·J G VanRooijF J Jongeneelen
Feb 26, 2000·The Annals of Occupational Hygiene·H BrandtM Castegnaro
Jul 24, 2003·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Catherine GaitanakiIsidoros Beis
Mar 3, 2007·Occupational and Environmental Medicine·Igor BurstynPaolo Boffetta

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Citations

Dec 14, 2011·The Annals of Occupational Hygiene·Jennifer M CavallariMichael D McClean
Jan 6, 2006·Journal of Environmental Monitoring : JEM·Virpi VäänänenPirjo Heikkilä

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