PMID: 2106258Mar 1, 1990Paper

Laboratory evaluation of jaundice in newborns. Frequency, cost, and yield

American Journal of Diseases of Children
T B NewmanD K Stevenson

Abstract

Neonates with hyperbilirubinemia commonly undergo a battery of laboratory tests. We used a computerized database and medical records to study the frequency, cost, and yield of these tests in 2443 infants born at the University of California, San Francisco, between 1980 and 1982. Four hundred forty-seven (18%) of the infants met standard criteria for "nonphysiologic" hyperbilirubinemia; the incidence varied from 9% in blacks to 31% in Asian infants. About 55% of these 447 infants received a $125 "hyperbilirubinemia workup." Hospital discharge diagnoses on all 447 hyperbilirubinemic infants were reviewed. In 214 (48%), no cause of the jaundice was identified. An additional 145 (32%) had a possible cause apparent from history, physical examination, or initial hematocrit determination. The only diagnosis made as a result of routine investigations of hyperbilirubinemia was possible ABO or Rh isoimmunization in 75 infants (17%). Nonphysiologic hyperbilirubinemia may be more common than previously reported. The recommended tests are expensive and rarely lead to diagnoses other than ABO or Rh isoimmunization. Their routine use should be reevaluated.

Citations

Feb 1, 1994·Clinical Pediatrics·T B Newman, M J Easterling
May 1, 1993·Archives of Disease in Childhood·K L Dodd
Jan 1, 1993·Journal of Community Health Nursing·J B CarlisleK Powell
May 4, 2013·Journal of Tropical Pediatrics·Feiliang WongAinoon Othman
Apr 13, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·W C Golden
Aug 7, 2020·Pediatric Research·Takumi ShibazakiUNKNOWN Japan Environment & Children’s Study (JECS) Group
Sep 30, 2008·Drug Metabolism Reviews·Young-Mi AhSang Geon Kim
Mar 7, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·M KaplanR Regev
Sep 4, 2004·Indian Journal of Pediatrics·Nooshin M FardFiroozeh Sajadi
Mar 12, 2020·Scientific Reports·Jana JašprováLibor Vítek
Mar 1, 1994·Clinical Pediatrics·B E MahonT B Newman
Nov 27, 1999·Postgraduate Medicine·K Melton, H T Akinbi
Nov 19, 2019·American Journal of Perinatology·Adil Abozaid EissaAdnan Anwar Al-Doski
Oct 28, 2009·Pediatrics·Jon F WatchkoUNKNOWN Pediatrix Hyperbilirubinemia Study Group
Apr 23, 2008·Pediatrics·Hasan OzkanNuray Duman
Jul 3, 2004·Pediatrics·UNKNOWN American Academy of Pediatrics Subcommittee on Hyperbilirubinemia
Feb 2, 1999·Pediatrics·M J Maisels, T B Newman
Jun 3, 2004·Pediatrics·M Jeffrey MaiselsRaywin Huang

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