Abstract
Lotilaner is approved for dogs as a chewable tablet formulation. It has separately been developed for oral administration in cats (Credelio™ chewable tablets for cats) to meet the need for an easy to use, safe and rapidly effective parasiticide and as an alternative to topical products. This paper describes two pivotal laboratory studies assessing the efficacy and speed of kill of lotilaner in cats against Ctenocephalides felis fleas following a single oral administration, at the minimum recommended dose rate of 6 mg/kg. Two GCP (Good Clinical Practice), blinded, randomized, negative-controlled, parallel-groups, laboratory studies were performed. In both studies, lotilaner was administered once, per os, at the minimum recommended dose of 6 mg/kg. Study 1 evaluated the efficacy of lotilaner tablets for cats against adult C. felis in experimentally infested cats, 24 h after treatment and after new weekly infestations, until day 35. Study 2 evaluated the speed of kill of lotilaner against C. felis, in cats, 8 and 12 h after treatment and after each subsequent weekly infestation, through day 35. In both studies, for each assessed time point, animals were randomized 1:1 to a lotilaner-treated or a contemporaneous negative control gr...Continue Reading
References
Jan 1, 1997·Annual Review of Entomology·M K Rust, M W Dryden
Jul 16, 2008·Veterinary Parasitology·C McCoyM W Dryden
Nov 26, 2009·The Veterinary Clinics of North America. Small Animal Practice·Byron L Blagburn, Michael W Dryden
Dec 1, 2009·Biochemical and Biophysical Research Communications·Yoshihisa OzoeTakeshi Mita
Oct 28, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Zahra HanaiziFrancesco Pignatti
Oct 2, 2012·Veterinary Parasitology·Michael W DrydenDaniel E Snyder
Mar 19, 2014·Veterinary Parasitology·Wesley L ShoopPat N Confalone
May 20, 2015·Clinical and Molecular Allergy : CMA·Carlo AgostiniEnrico Maggi
May 23, 2015·Veterinary Parasitology·Marie Varloud, Josephus J Fourie
Nov 11, 2015·Parasites & Vectors·Daniel E SnyderWilliam G Ryan
Mar 11, 2016·Veterinary Parasitology·Tom L McTierPatrick Meeus
Nov 2, 2017·Parasites & Vectors·Susan E Little
Jul 14, 2018·Parasites & Vectors·Céline E ToutainMartin Jung
Jul 14, 2018·Parasites & Vectors·Daniela CavalleriSteve Nanchen
Jul 14, 2018·Parasites & Vectors·Daniela CavalleriSteve Nanchen
Jul 14, 2018·Parasites & Vectors·Emmanuelle A Kuntz, Srinivas Kammanadiminti
Citations
Jul 14, 2018·Parasites & Vectors·Daniela CavalleriSteve Nanchen
Oct 3, 2020·Insects·Michael K Rust
Jul 14, 2018·Parasites & Vectors·Ian Wright
Jul 14, 2018·Parasites & Vectors·Daniela CavalleriSteve Nanchen
Jul 14, 2018·Parasites & Vectors·Daniela CavalleriSteve Nanchen
Mar 7, 2021·Parasites & Vectors·Tandy PaarlbergRainer Helbig
Mar 3, 2021·Parasites & Vectors·Kimberly ChappellSteve Nanchen
Mar 19, 2021·Journal of Veterinary Pharmacology and Therapeutics·Xueying ZhouWalter H Hsu