Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America

Parasites & Vectors
Martin MurphySteve Nanchen

Abstract

Effective control of tick infestations on dogs is important to reduce the risk of transmission of bacterial, viral, and protozoal pathogens. Laboratory studies were initiated to determine the efficacy of lotilaner against common ticks infesting dogs in the United States. Eight studies investigated the efficacy of lotilaner against ticks. In two studies dogs were infested with both Dermacentor variabilis and Rhipicephalus sanguineus: one additional study was completed for each of these species. Two studies assessed infestations with Amblyomma americanum and two with Ixodes scapularis. In all studies, dogs were ranked and blocked by counts from pre-treatment infestations and randomly allocated, at least eight per group, to be treated orally with lotilaner (minimum dose rate 20 mg/kg), or to be untreated controls. Treatments were administered on Day 0, within 30 min after dogs were fed. In all studies, infestations were performed with 50 adult ticks on Days -2, 7, 14, 21 and 28, and also on Day 35 for R. sanguineus, D. variabilis and I. scapularis. Tick counts were completed 48 h after treatment or after each subsequent challenge. An adequate infestation was defined as at least 25% of the infestation dose recovered from each of at...Continue Reading

References

Oct 21, 2005·Archives of Environmental Contamination and Toxicology·S K ObendorfT Dokuchayeva
Nov 26, 2009·The Veterinary Clinics of North America. Small Animal Practice·Byron L Blagburn, Michael W Dryden
Mar 19, 2014·Veterinary Parasitology·Wesley L ShoopPat N Confalone
Apr 2, 2014·Veterinary Parasitology·Elizabeth B MitchellDiane Larsen
May 20, 2015·Clinical and Molecular Allergy : CMA·Carlo AgostiniEnrico Maggi
Nov 2, 2017·Parasites & Vectors·Céline E ToutainMartin Jung
Nov 2, 2017·Parasites & Vectors·Daniela CavalleriSteve Nanchen

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Citations

Nov 2, 2017·Parasites & Vectors·Susan E Little
Jul 14, 2018·Parasites & Vectors·Céline E ToutainMartin Jung
Oct 3, 2020·Insects·Michael K Rust
Nov 2, 2017·Parasites & Vectors·Emmanuelle A Kuntz, Srinivas Kammanadiminti
Jul 14, 2018·Parasites & Vectors·Emmanuelle A Kuntz, Srinivas Kammanadiminti
Oct 9, 2020·ChemMedChem·Gulshan Kumar, Ravi Shankar
Mar 19, 2021·Journal of Veterinary Pharmacology and Therapeutics·Xueying ZhouWalter H Hsu
Nov 16, 2021·Veterinary Dermatology·Braulio Alejandro Fuatos GámezCamilo Romero Núñez

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Methods Mentioned

BETA
sedation

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