Laboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015-A Retrospective Observational Study.

The Journal of Infectious Diseases
Romy KerberStephan Günther

Abstract

In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea, confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola virus-specific reverse transcription-polymerase chain reaction assay and 13 blood chemistry parameters were measured on admission and during hospitalization. Favipiravir treatment was offered to patients with EVD on a compassionate-use basis. To reduce biases in the raw field data, we carefully selected 163 of 286 patients with EVD for a retrospective study to assess associations between potential risk factors, alterations in blood chemistry findings, favipiravir treatment, and outcome. The case-fatality rate in favipiravir-treated patients was lower than in untreated patients (42.5% [31 of 73] vs 57.8% [52 of 90]; P = .053 by univariate analysis). In multivariate regression analysis, a higher Ct and a younger age were associated with survival (P < .001), while favipiravir treatment showed no statistically significant effect (P = .11). However, Kaplan-Meier analysis indicated a longer survival time in the favipiravir-treated group (P = .015). The study also showed characteristic changes in blood chemistry findings in patients who died, compared with survivors. Consiste...Continue Reading

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Citations

Mar 22, 2020·CPT: Pharmacometrics & Systems Pharmacology·Vincent MadelainJérémie Guedj
Aug 14, 2020·ILAR Journal·Steven M Niemi
Sep 29, 2020·Internal and Emergency Medicine·Palumbo RobertoDominijanni Sara
Jul 1, 2020·The Lancet Infectious Diseases·Michael Ramharter, Stephan Günther
Dec 7, 2019·Journal of Autoimmunity·Manuel RojasJuan-Manuel Anaya
Jul 20, 2020·Antiviral Research·Thomas R LaneSean Ekins
Aug 25, 2020·American Journal of Obstetrics & Gynecology MFM·Margaux LouchetLaurent Mandelbrot
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammad HailatWael Abu Dayyih

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