Laboratory findings, histopathology, and immunophenotype of lymphoma in domestic ferrets

Veterinary Pathology
M AmmersbachD Bienzle

Abstract

Lymphoma is a common tumor in ferrets, but anatomic distribution, histomorphology, immunophenotype, laboratory abnormalities, and response to chemotherapy are incompletely defined. In this study, lymphoma was diagnosed by histopathology of tumor tissue in 29 ferrets ranging in age from 0.8 to 8.5 years, including 12 males and 17 females. Tumors involved the viscera of the abdominal cavity (n = 11), thoracic cavity (n = 1), or abdominal and thoracic cavities (n = 7); the skin (n = 2); or the viscera of both body cavities plus other sites (n = 8). Microscopically, all tumors had diffuse architecture. Assessment by histomorphology and immunophenotype classified tumors as peripheral T-cell lymphoma (n = 17), anaplastic large T-cell lymphoma (n = 5), anaplastic large B-cell lymphoma (n = 4), diffuse large B-cell lymphoma (n = 1), and Hodgkin-like lymphoma (n = 2). Cytologic evaluation of tumor tissue was diagnostic in 11 of 13 cases. Twenty-two of 27 ferrets had anemia, 2 had leukemia, and 5 were neutropenic. Common comorbid disorders were adrenal disease (n = 27) and insulinoma (n = 6). Tumors most frequently involved mesenteric lymph nodes, while enlargement of peripheral lymph nodes was uncommon (n = 3). Ferrets with Hodgkin-like...Continue Reading

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Citations

Jun 22, 2012·PloS One·Zhiqiang SongWenjing Sun
Sep 14, 2012·The Journal of Veterinary Medical Science·Hitoshi ArataniTakeo Sakai
Jun 7, 2013·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Jantra Ngosuwan Suran, Nicole Rene Wyre
Nov 26, 2010·Veterinary Dermatology·Stefanie KoebrichSylvia Wilhelm
Feb 21, 2014·Diagnostic Cytopathology·Leslie C SharkeyJed Overmann
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Mar 12, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Atigan ThongtharbHiroyuki Nakayama
Sep 21, 2013·Veterinary Pathology·B VidañaJ Martínez
Mar 31, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Megan K WatsonKaori Sakamoto
Aug 21, 2013·SpringerPlus·Bamdad ZendehbadHussein Zendehbad
Nov 11, 2021·Journal of the American Veterinary Medical Association·Amanda D WongHugues Beaufrère

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Methods Mentioned

BETA
biopsy
electrophoresis

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