Laboratory-induced stress and craving among individuals with prescription opioid dependence

Drug and Alcohol Dependence
Sudie E BackJenna L McCauley

Abstract

Stress and conditioned drug cues have been implicated in the initiation, maintenance and relapse to substances of abuse. Although stress and drug cues are often encountered together, little research exists on whether stress potentiates the response to drug cues. Participants (N=75) were 39 community recruited individuals with current prescription opioid (PO) dependence and 36 healthy controls. Participants stayed overnight in the hospital for one night and then completed laboratory testing the following morning. During laboratory testing, participants were randomly assigned to a stress task (Trier Social Stress Task; TSST) or a no-stress condition. Following the stress manipulation, all participants completed a PO cue paradigm. Immediately before and after the stress and cue tasks, the following were assessed: subjective (stress, craving, anger, sadness, happiness), physiological (heart rate, blood pressure, galvanic skin response), and neuroendocrine responses (cortisol and dehydroepiandrosterone). Internal validity of the stress task was demonstrated, as evidenced by significantly higher subjective stress, as well as cortisol, heart rate and blood pressure in the TSST compared to the no-stress group. Individuals with PO depen...Continue Reading

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Citations

Jul 2, 2016·Alcoholism, Clinical and Experimental Research·Elizabeth RalevskiIsmene Petrakis
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Jan 12, 2021·Current Addiction Reports·Albert Burgess-Hull, David H Epstein
Sep 28, 2021·The American Journal on Addictions·Aisling V HenschelSudie E Back

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