Laboratory transmission of Japanese encephalitis and West Nile viruses by molestus form of Culex pipiens (Diptera: Culicidae) collected in Uzbekistan in 2004

Journal of Medical Entomology
Michael J TurellS Khodjaev

Abstract

We evaluated the molestus form of Culex pipiens pipiens (L.) (hereafter referred to as "molestus") captured near Tashkent, Uzbekistan, for their ability to transmit Japanese encephalitis (family Flaviviridae, genus Flavivirus, JEV) and West Nile (family Flaviviridae, genus Flavivirus, WNV) viruses under laboratory conditions. These molestus were highly competent laboratory vectors of WNV, with infection and dissemination rates of 96 and 81%, respectively. Approximately 75% of female molestus that fed after development of a disseminated infection transmitted virus by bite. Therefore, approximately 60% of those molestus taking a second bloodmeal between 16 and 25 d after an infectious bloodmeal would be expected to transmit WNV by bite. In contrast, these molestus were less efficient vectors of JEV, with infection and dissemination rates of 51 and 25%, respectively. In addition, only 33% of individuals with a disseminated infection transmitted JEV by bite, indicating a significant salivary gland barrier. Therefore, only approximately 8% of orally exposed individuals would be expected to transmit JEV by bite if they took a second bloodmeal 16-25 d later. These data indicate that the molestus form of Cx. p. pipiens should be consid...Continue Reading

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Citations

Jan 28, 2014·International Journal of Environmental Research and Public Health·Alexander E PlatonovGiovanni Rezza
May 30, 2014·The Journal of Infectious Diseases·Christopher N MoresSilas A Davidson
Oct 27, 2009·Journal of the American Mosquito Control Association·Christopher J VitekChelsea T Smartt
Sep 13, 2007·Journal of the American Mosquito Control Association·Thomas BalenghienDominique J Bicout
Oct 22, 2016·The Clinical Neuropsychologist·Eli Vakil, Dan Hoofien
Feb 14, 2013·Journal of the American Mosquito Control Association·Michael J Turell
Nov 9, 2017·Emerging Microbes & Infections·Chantal Bf VogelsConstantianus Jm Koenraadt

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