Labour analgesia with intrathecal fentanyl decreases maternal stress

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
M CascioS Ramanathan

Abstract

Lumbar epidural analgesia (LEA) decreases maternal stress as measured by maternal circulating plasma catecholamine concentrations. Intrathecal fentanyl (ITF) provides effective labour analgesia but its effect on maternal epinephrine (Epi) and norepinephrine (NE) concentrations is not known. This study assesses whether ITF reduces maternal stress in the same manner as conventional LEA. Twenty-four healthy women in active labour received either 25 micrograms ITF (n = 12) or epidural lidocaine 1.5% (n = 12) for analgesia. Venous blood samples were collected before anaesthesia and at five minute intervals for 30 min following anaesthesia for the measurement of plasma Epi and NE by high performance liquid chromatography. Maternal blood pressure (BP), heart rate (HR), visual analog scores (VAS) to pain and pruritus were recorded at the same time. Both ITF and LEA decreased pain VAS scores, maternal BP, and plasma Epi concentrations with only minimal effects on plasma NE concentrations. Intrathecal fentanyl (ITF) and LEA reduced plasma epi to a similar extent, with ITF reducing the levels slightly faster than LEA. Intrathecal fentanyl(ITF) and LEA reduced plasma Epi concentrations by 52% and 51%, respectively (P value < 0.01). We conc...Continue Reading

References

Nov 1, 1978·American Journal of Obstetrics and Gynecology·R P LedermanD S McCann
Sep 1, 1977·American Journal of Obstetrics and Gynecology·R P LedermanM J Huber
May 1, 1975·American Journal of Obstetrics and Gynecology·R E Myers
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·K Häkkinen, A Pakarinen
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·A H van den MeirackerM A Schalekamp
Jul 11, 1970·Lancet·M CarruthersD Bates
Sep 1, 1983·American Journal of Obstetrics and Gynecology·S M ShniderG Levinson
Feb 1, 1982·American Journal of Obstetrics and Gynecology·T K AbboudR K Kammula
Dec 15, 1982·American Journal of Obstetrics and Gynecology·T AbboudR K Kammula
Apr 15, 1981·American Journal of Obstetrics and Gynecology·E LedermanD S McCann
Jan 25, 1980·JAMA : the Journal of the American Medical Association·J E Dimsdale, J Moss
Aug 1, 1995·Journal of Clinical Pharmacy and Therapeutics·N BrittenA Herxheimer
Oct 1, 1962·American Journal of Obstetrics and Gynecology·F P ZUSPANS V POSE

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Citations

Sep 4, 2012·International Journal of Obstetric Anesthesia·F JaimeG Allen
Sep 16, 2000·Journal of Pain and Symptom Management·G BennettT Yaksh
Aug 24, 2004·International Journal of Obstetric Anesthesia·Anita Holdcroft, Daryl Dob
Apr 13, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Chahé MardirosoffMartin R Tramèr
Feb 18, 2005·The New England Journal of Medicine·Cynthia A WongSharon Grouper
Jan 19, 2002·Regional Anesthesia and Pain Medicine·Brenda A BucklinJoy L Hawkins
Sep 10, 2003·CNS Drugs·Peter DeBalli, Terrance W Breen
Jan 15, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·L ArnaoutA Mignon
Sep 28, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G Capogna
Jul 3, 2013·Revista española de anestesiología y reanimación·J Pascual-RamírezJ M Valverde Mantecón
Feb 2, 2010·Revista española de anestesiología y reanimación·M Van de Velde
Jan 18, 2006·Anaesthesia·K SaravanakumarG M Cooper
May 16, 2002·American Journal of Obstetrics and Gynecology·Linda J MayberryAnindya De
Feb 14, 2007·The Journal of International Medical Research·N KayacanM Erman
Oct 19, 2001·Anesthesiology·M C NorrisC Conway-Long
Sep 2, 2005·Obstetrics and Gynecology·Jane Cleary-GoldmanPamela Flood
Apr 11, 2008·European Journal of Anaesthesiology·J NicoletA Deschamps
Feb 23, 2008·Anesthesia and Analgesia·Scott Segal, Steven Y Wang
Oct 13, 1998·Anesthesia and Analgesia·S SegalS Datta
May 18, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Silvia PomaGiorgio Antonio Iotti
Oct 3, 2006·Current Opinion in Anaesthesiology·G M Vasdev, M T Keegan
Jun 17, 2020·Chinese Medical Journal·Zhi-Hua Liu, Dong-Xin Wang
Jul 24, 2001·Anesthesiology·S R Verma, F Plaat
Mar 17, 2021·Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·Lisa Töpel, Manuel Wenk

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