Labyrinthitis Ossificans: On the Mechanism of Perilabyrinthine Bone Remodeling

The Annals of Otology, Rhinology, and Laryngology
Sune Land BlochMorten Friis

Abstract

It has been suggested that remodeling of the otic capsule is highly suppressed by the action of anti-resorptive signals emanating from structures of the inner ear space. Labyrinthitis ossificans (LO) is a severe complication to bacterial meningitis and is characterized by destruction of inner ear structures by the formation of new bone. The aim of this study was to explore the impact of LO on bone remodeling of the otic capsule. In 11 human temporal bones with extensive LO and 10 control specimens, the degree of bone remodeling was explored indirectly by estimating the viability of osteocytes in perilabyrinthine bone and the mastoid. The viability of osteocytes was significantly lower in the perilabyrinthine bone compared to the mastoid in both groups. However, the loss of perilabyrinthine osteocytes was the same in the 2 groups, and the presence of cartilage remnants appeared to be the same. This study indicates that the factors affecting bone remodeling of the otic capsule and the degeneration of osteocytes are not altered by wholesale destruction of inner ear soft tissue and its replacement by bone. Therefore, alternative mechanisms may be implicated in the suppression of capsular bone remodeling.

References

Sep 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M A NovakJ B Firszt
Aug 1, 1971·Archives of Otolaryngology·I KakizakiF Altmann
Aug 1, 1967·The Annals of Otology, Rhinology, and Laryngology·M M Paparella, S Sugiura
Jan 29, 2000·The Annals of Otology, Rhinology, and Laryngology·T FrischP Bretlau
Jan 5, 2005·The Laryngoscope·Andreas F ZehnderMichael J McKenna
Feb 16, 2005·Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris·S TringaliCh Martin
Mar 11, 2005·The Annals of Otology, Rhinology, and Laryngology·Steven P TinlingHilary A Brodie
Sep 9, 2006·The Journal of Biological Chemistry·Keiichi InoueShigeyoshi Itohara
Sep 1, 1948·The Annals of Otology, Rhinology, and Laryngology·B J ANSONE W CAULDWELL
Nov 10, 2009·Acta Oto-laryngologica·Sune Land Bloch, Mads Sølvsten Sørensen
Feb 12, 2010·Hearing Research·Konstantina M StankovicMichael J McKenna
May 12, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sune Land BlochMads Sølvsten Sørensen
Dec 18, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Sune Land Bloch, Mads Sølvsten Sørensen

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Citations

Jun 3, 2017·The Laryngoscope·Jeffrey T Vrabec

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