PMID: 9431858Feb 12, 1998Paper

Lacidipine, hydrochlorothiazide and their combination in systolic hypertension in the elderly

Journal of Hypertension
L M WingJ P Chalmers

Abstract

To compare with placebo the efficacies of once-daily administrations of lacidipine and hydrochlorothiazide separately and in combination to elderly patients with systolic hypertension. Nineteen elderly subjects (five men and 14 women, median age 71 years, range 62-79 years) participated in the study, which had a randomized double-blind crossover design. For each subject there were four treatment phases, each of duration 4 weeks. The initial treatments in each phase were 2 mg lacidipine once a day and 25 mg hydrochlorothiazide once a day, separately and in combination, and placebo. Doses of each agent could be doubled after 2 weeks in each phase if the patient's goal systolic blood pressure had not been achieved. The numbers of subjects administered the higher dose of each treatment were 13 for placebo, 14 for lacidipine, 11 for hydrochlorothiazide and eight for lacidipine plus hydrochlorothiazide. End-of-phase mean clinic blood pressures were 164/85 mmHg with placebo, 159/82 mmHg with lacidipine, 157/84 mmHg with hydrochlorothiazide and 152/82 mmHg with lacidipine plus hydrochlorothiazide. Systolic blood pressure was significantly reduced during all active treatment phases compared with placebo and that for the lacidipine plus ...Continue Reading

References

Jan 1, 1991·Journal of Cardiovascular Pharmacology·D MicheliG Gaviraghi
Jan 1, 1991·Journal of Cardiovascular Pharmacology·S T HallP Rizzini
Jan 1, 1988·Journal of Cardiovascular Pharmacology·F R Bühler
Mar 1, 1989·American Journal of Hypertension·S P GlasserD K Koehn
Dec 1, 1987·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P S Sever, N R Poulter
Jan 1, 1987·American Journal of Nephrology·G A MacGregorN D Markandu
Dec 1, 1985·The American Journal of Cardiology·S B HulleyT M Vogt
Nov 1, 1983·Journal of Cardiovascular Pharmacology·L HallinL Hansson
Apr 1, 1993·Journal of Hypertension·M F O'Rourke, R P Kelly

❮ Previous
Next ❯

Citations

Jan 29, 2011·Journal of the American College of Cardiology·Franz H MesserliSripal Bangalore
May 30, 2014·The Cochrane Database of Systematic Reviews·Vijaya M MusiniJames M Wright
Jul 28, 1999·Clinical and Experimental Hypertension : CHE·J Chalmers
Nov 5, 2003·Blood Pressure·Lindon M H WingDanielle Molloy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.