PMID: 8957145Dec 2, 1996Paper

Lack of a pharmacologic interaction between rifabutin and methadone in HIV-infected former injecting drug users

Drug and Alcohol Dependence
L S BrownP K Narang

Abstract

Rifampin, an agent known to decrease the half-life of methadone, and rifabutin are two rifamycins that are structurally similar and share mechanisms of action. Hence the possibility of a drug-drug interaction between rifabutin and methadone was evaluated in 24 methadone-maintained, former injecting drug users infected with the human immunodeficiency virus. The study was an open-label, drug-drug interaction and safety trial in which patients were followed for 15 days. Each patient received rifabutin 300 mg as a single dose concomitantly with their individualized methadone dosage. No significant differences in methadone peak plasma concentration, time to peak plasma concentration, area under the plasma concentration-time curve, systemic clearance or renal clearance was observed in the presence of rifabutin. Seventy-five percent of the patients reported at least one symptom of narcotic withdrawal during the study, however, these symptoms were mild. A relationship between the development of narcotic withdrawal and methadone systemic exposure could not be established. Concurrent administration of rifabutin and methadone appeared to be safe in human immunodeficiency virus-infected injecting drug users maintained on stable doses of me...Continue Reading

References

Jan 1, 1976·Annals of the New York Academy of Sciences·M J KreekF H Field
May 13, 1976·The New England Journal of Medicine·M J KreekL M Giusti
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·V P Dole, M J Kreek
Oct 1, 1972·Annals of Internal Medicine·M J KreekR Martin
Aug 1, 1973·Journal of Medicinal Chemistry·H R Sullivan, S L Due
Sep 16, 1993·The New England Journal of Medicine·S D NightingaleD L Kaufman

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Citations

Dec 3, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert G DeissRichard S Garfein
Jan 30, 2004·Annual Review of Medicine·Bouke C de JongPeter M Small
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Henry M BlumbergUNKNOWN American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society
Apr 4, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Douglas J WeschulesSteven Richeimer
Mar 25, 2016·The Journal of Antimicrobial Chemotherapy·Yoann CrabolOlivier Lortholary
Nov 1, 2011·Critical Reviews in Clinical Laboratory Sciences·Bhushan M KapurPeter Selby
May 21, 2011·Drug and Alcohol Dependence·Elinore F McCance-KatzPetrie M Rainey
Jan 4, 2001·Substance Use & Misuse·B K Boyarsky, E F McCance-Katz
Oct 9, 2019·Antimicrobial Agents and Chemotherapy·Russell R KempkerCharles A Peloquin
Aug 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert C StevensRichard Bertz
Jun 19, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J G GerberUNKNOWN ACTG 401 Study Team
Aug 13, 2020·Infectious Disease Clinics of North America·David P SerotaMarcos C Schechter
Mar 23, 2021·Pharmacotherapy·Eric M KinneyBranden D Nemecek

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