PMID: 7026261Jan 1, 1981Paper

Lack of adrenergic influence on renin release after furosemide in normal man

European Journal of Clinical Pharmacology
J ElmgreenN J Christensen

Abstract

The role of the sympathetic nervous system in furosemide-induced renin release was investigated in six normal subjects. After intravenous administration of furosemide, plasma renin concentrations increased more than two-fold within 15 min. Neither replacement of urinary fluid loss by intravenous infusion of saline nor pharmacological beta-blockade with d,1-propranolol changed the renin response to furosemide. The activity of the sympathetic nervous system, as estimated by measurement of plasma catecholamine concentrations, remained at the reference level after furosemide. It is concluded that the sympathetic nervous system is not involved in renin release after intravenous administration of furosemide.

References

May 1, 1979·Circulation Research·M D Thames, G F DiBona
Feb 22, 1978·Pflügers Archiv : European journal of physiology·B GrandjeanJ Sassard
May 1, 1975·Clinical and Experimental Pharmacology & Physiology·R J NaughtonS L Skinner
Apr 4, 1975·European Journal of Clinical Pharmacology·P O AttmanG Johnsson
Jan 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·B Hesse, I Nielsen
Aug 1, 1973·Clinical Science and Molecular Medicine·N J Christensen

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Citations

May 18, 1999·Pharmacology & Toxicology·J S Petersen
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·H A Struyker-BoudierH van Essen

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